Antisense mapping KOR-1: Evidence for multiple kappa analgesic mechanisms Journal Article
| Authors: | Pasternak, K. R.; Rossi, G. C.; Zuckerman, A.; Pasternak, G. W. |
| Article Title: | Antisense mapping KOR-1: Evidence for multiple kappa analgesic mechanisms |
| Abstract: | In binding assays, both dynorphin B and alpha-neoendorphin are relatively selective for the kappa,, site, unlike U50,488H which has high affinity for both kappa(1a) and kappa(1b) sites. In vivo, U50,488H, dynorphin B and alpha-neoendorphin analgesia are reversed by the kappa(1)-selective antagonist, nor-binaltorphimine (norBNI). Antisense mapping the three exons of KOR-1 revealed that probes targeting all three exons blocked U50,488H analgesia, as expected. However, the selectivity profile of dynorphin B and alpha-neoendorphin analgesia towards the various antisense oligodeoxynucleotides differed markedly from U50,488H, implying a different receptor mechanism of action. (C) 1999 Elsevier Science B.V. All rights reserved. |
| Keywords: | opiate; opioid; analgesia; antisense mapping; opioid receptor; binding; drugs; potent; guinea-pig brain; kappa; molecular-biology; oligodeoxynucleotides; dynorphin b; kappa(1) receptor; alpha-neoendorphin |
| Journal Title: | Brain Research |
| Volume: | 826 |
| Issue: | 2 |
| ISSN: | 0006-8993 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1999-05-01 |
| Start Page: | 289 |
| End Page: | 292 |
| Language: | English |
| ACCESSION: | WOS:000080057100014 |
| DOI: | 10.1016/s0006-8993(99)01294-9 |
| PROVIDER: | wos |
| PUBMED: | 10224306 |
| Notes: | Article -- Source: Wos |
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