| Abstract: |
Development of the vertebrate central nervous system is thought to be controlled by intricate cell-cell interactions and spatio-temporally regulated gene expressions. The details of these processes are still not fully understood. We have isolated a novel vertebrate gene, CRIM1/Crim1, in human and mouse. Human CRIM1 maps to chromosome 2p21 close to the Spastic Paraplegia 4 locus. Crim1 is expressed in the notochord, somites, floor plate, early motor neurons and interneuron subpopulations within the developing spinal cord. CRIM1 appears to be evolutionarily conserved and encodes a putative transmembrane protein containing an IGF-binding protein motif and multiple cysteine-rich repeats similar to those in the BMP-associating chordin and sog proteins. Our results suggest a role for CRIM1/Crim1 in CNS development possibly via growth factor binding. Copyright (C) 2000 Elsevier Science Ireland Ltd. |
| Keywords: |
adult; controlled study; human tissue; nonhuman; proteins; mouse; animals; mice; animal tissue; gene expression; embryo; protein binding; membrane proteins; gene locus; embryo development; evolution; chromosomes, human, pair 2; time; evolution, molecular; nuclear proteins; vertebrata; in situ hybridization; molecular cloning; gene expression regulation, developmental; gene mapping; fluorescence in situ hybridization; amino acid sequence; conserved sequence; molecular sequence data; sequence homology, amino acid; tissue distribution; brain; messenger rna; rna, messenger; brain development; interneuron; spinal cord; membrane protein; gene control; proto-oncogene proteins c-myc; cell interaction; growth factor; blotting, northern; vertebrate; vertebrates; motor neuron; cysteine; complementary dna; gene structure; organogenesis; transforming growth factor-β; motoneuron; c. elegans; coding; notochord; restriction mapping; gene isolation; chromosome 2p; floor plate; somite; humans; human; female; priority journal; article; bone morphogenic protein; chordin; invertebrates; cysteine-rich repeat; insulin-like growth factor binding protein; short gastrulation; spastic paraplegia type 4; cns development; hereditary essential tremor 2, human; holoprosencephaly 2
|
