Metalloprotease-disintegrins: Modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding Journal Article
| Authors: | Schlöndorff, J.; Blobel, C. P. |
| Article Title: | Metalloprotease-disintegrins: Modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding |
| Abstract: | Metalloprotease-disintegrins (ADAMs) have captured our attention as key players in fertilization and in the processing of the ectodomains of proteins such as tumor necrosis factor or (TNFα), and because of their roles in Notch-mediated signaling, neurogenesis and muscle fusion, ADAMs are integral membrane glycoproteins that contain a disintegrin domain, which is related to snake-venom integrin ligands, and a metalloprotease domain (which can contain or lack a catalytic site). Here, we review and critically discuss current topics in the ADAMs field, including the central role of fertilin in fertilization, the role of the TNFα convertase in protein ectodomain processing, the role of Kuzbanian in Notch signaling, and links between ADAMs and processing of the amyloid-precursor protein. |
| Keywords: | signal transduction; unclassified drug; note; animals; protein processing; tumor necrosis factor alpha; membrane protein; ligand; protein structure, tertiary; cell interaction; cell communication; nervous system development; integrin; metalloproteinase; amyloid precursor protein; enzyme active site; muscle; enzyme; ectodomain; fertilization; disintegrin; metalloendopeptidases; snake venom; priority journal; serpentes; convertase |
| Journal Title: | Journal of Cell Science |
| Volume: | 112 |
| Issue: | 21 |
| ISSN: | 0021-9533 |
| Publisher: | Company of Biologists |
| Date Published: | 1999-11-01 |
| Start Page: | 3603 |
| End Page: | 3617 |
| Language: | English |
| PUBMED: | 10523497 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Note -- Export Date: 16 August 2016 -- Source: Scopus |
