State-of-the-art approaches to sentinel node biopsy for breast cancer: Study design, patient selection, technique, and quality control at Memorial Sloan-Kettering Cancer Center Journal Article

  

Authors:	Cody, H. S. 3rd; Borgen, P. I.
Article Title:	State-of-the-art approaches to sentinel node biopsy for breast cancer: Study design, patient selection, technique, and quality control at Memorial Sloan-Kettering Cancer Center
Abstract:	Sentinel lymph node (SLN) biopsy has the potential to become a standard operation for most patients with operable breast cancer, but raises a number of issues for the surgeon and institution wishing to start a SLN program. We began to perform SLN biopsy for breast cancer at Memorial Sloan-Kettering Cancer Center in September of 1996. Based on a pilot study of 60 patients, detailed analyses of our first 500 and 1000 cases, and a cumulative experience of 1500 procedures, we report the lessons learned in starting a SLN program, emphasizing study design, case selection, technique and quality control. All patients had clinical T1-2N0 breast cancers and isotope plus blue dye mapping. The combination of blue dye and isotope localization was superior to either method alone, unfiltered technetium sulfur colloid was superior to filtered, and optimum isotope localization was achieved with a low-volume, low-dose intradermal injection. In our first 1000 cases, 14% of SLN were found by isotope alone, and 8% by dye alone. 10% of positive SLN were found by isotope alone, and 11% by dye alone. Failed and false-negative SLN procedures were less frequent as experience increased. Copyright (C) 2000 Elsevier Science Ltd.
Keywords:	immunohistochemistry; controlled study; human tissue; major clinical study; review; patient selection; research design; follow up; lymph nodes; lymphatic metastasis; sensitivity and specificity; lymph node excision; quality control; breast cancer; health survey; breast neoplasms; pilot projects; biopsy, needle; new york city; biopsy technique; dye; lymph node biopsy; breast biopsy; academic medical centers; humans; human; female; priority journal
Journal Title:	Surgical Oncology
Volume:	8
Issue:	2
ISSN:	0960-7404
Publisher:	Elsevier Inc.
Date Published:	1999-08-01
Start Page:	85
End Page:	91
Language:	English
DOI:	10.1016/s0960-7404(99)00029-8
PUBMED:	10732960
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033500675&partnerID=40&md5=e9f973232741654f9dc32cbf4779317d
Notes:	Review -- Export Date: 16 August 2016 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/97196