The biological significance of failure at the primary site on ultimate survival in soft tissue sarcoma Journal Article
| Authors: | Espat, N. J.; Lewis, J. J. |
| Article Title: | The biological significance of failure at the primary site on ultimate survival in soft tissue sarcoma |
| Abstract: | Local tumor recurrence after complete resection may be due to treatment factors or represent a manifestation of tumor biology. The association of local tumor recurrence, distant metastases, and death in patients undergoing treatment for extremity soft tissue sarcoma (STS) has been described but continues to be enigmatic. After definitive multimodality treatment for extremity STS, local tumor recurrence is associated with development of distant metastasis, and metastases are implicated in subsequent disease- specific death. The relationship is an enigma, and the causality is unclear. Conversely, for patients with retroperitoneal STS, a direct relationship between local tumor recurrence and disease-specific death has been shown. In this article, current concepts are analyzed and reviewed. |
| Keywords: | cancer survival; treatment outcome; disease-free survival; survival rate; treatment failure; clinical trial; review; cancer localization; cancer recurrence; combined modality therapy; metastasis; neoplasm recurrence, local; cancer mortality; sarcoma; neoplasm metastasis; amputation; limb tumor; soft tissue sarcoma; extremities; soft tissue neoplasms; retroperitoneal space; retroperitoneal sarcoma; humans; human; priority journal |
| Journal Title: | Seminars in Radiation Oncology |
| Volume: | 9 |
| Issue: | 4 |
| ISSN: | 1053-4296 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1999-10-01 |
| Start Page: | 369 |
| End Page: | 377 |
| Language: | English |
| DOI: | 10.1016/s1053-4296(99)80031-9 |
| PUBMED: | 10516384 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 16 August 2016 -- Source: Scopus |
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