Primary central nervous system lymphoma Journal Article
| Author: | DeAngelis, L. M. |
| Article Title: | Primary central nervous system lymphoma |
| Abstract: | Primary central nervous system (CNS) lymphoma is an unusual but increasingly frequent brain tumor being identified by neurologists. Considerable improvements in survival have been accomplished by the addition of chemotherapy to cranial radiotherapy. In addition, many patients achieve substantial disease free survival with chemotherapy alone, and survival is superior to radiotherapy alone. Currently, every patient should be considered for chemotherapy as the first line of treatment. Subsequent cranial radiotherapy may or may not be necessary depending upon the patient's clinical condition, age and response to initial chemotherapy. Intensification of multi-agent chemotherapy is under study and it is anticipated that the incidence of neurotoxicity will reduce with elimination of combined modality treatment. (C) 1999 Lippincott Williams and Wilkins. |
| Keywords: | adult; cancer chemotherapy; cancer survival; human tissue; aged; prednisone; clinical feature; review; doxorubicin; cancer growth; drug penetration; radiation dose; cytarabine; methotrexate; brain radiation; neurotoxicity; nuclear magnetic resonance imaging; computer assisted tomography; cyclophosphamide; dexamethasone; vincristine; procarbazine; thiotepa; central nervous system tumor; high risk patient; central nervous system neoplasms; blood brain barrier; lymphoma; bleomycin; acquired immune deficiency syndrome; cancer classification; corticosteroid; immunosuppressive treatment; brain biopsy; epstein barr virus; leukoencephalopathy; immunocompetence; immunosuppressive agent; zidovudine; lamivudine; brain lymphoma; saquinavir; humans; human; male; female |
| Journal Title: | Current Opinion in Neurology |
| Volume: | 12 |
| Issue: | 6 |
| ISSN: | 1350-7540 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1999-12-01 |
| Start Page: | 687 |
| End Page: | 691 |
| Language: | English |
| DOI: | 10.1097/00019052-199912000-00005 |
| PUBMED: | 10676749 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 16 August 2016 -- Source: Scopus |
