Technology evaluation: Gene therapy (mesothelioma), NCI Journal Article
| Author: | Banerjee, D. |
| Article Title: | Technology evaluation: Gene therapy (mesothelioma), NCI |
| Abstract: | The National Cancer Institute is sponsoring a phase I clinical trial by the University of Pennsylvania involving administration of recombinant adenovirus containing the HSV-tk gene and subsequent tumor kill by ganciclovir, for the gene therapy of malignant mesothelioma. Twenty one patients have been enrolled into the trial. |
| Keywords: | clinical article; controlled study; treatment outcome; clinical trial; review; nonhuman; united states; gene targeting; controlled clinical trial; liver toxicity; anemia; bone marrow suppression; blood toxicity; genetic vectors; fever; rash; organ specificity; gene therapy; simplexvirus; malignant mesothelioma; mesothelioma; thymidine kinase; ganciclovir; pleural neoplasms; national institutes of health (u.s.); intravenous drug administration; adenoviridae; viral proteins; virus vector; prodrugs; adenovirus; universities; pennsylvania; defective viruses; tumor stem cells; adenoviruses, human; human |
| Journal Title: | Current Opinion in Molecular Therapeutics |
| Volume: | 1 |
| Issue: | 4 |
| ISSN: | 1464-8431 |
| Publisher: | Thomson Reuters |
| Date Published: | 1999-01-01 |
| Start Page: | 517 |
| End Page: | 520 |
| Language: | English |
| PUBMED: | 11713768 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 16 August 2016 -- Source: Scopus |
