A G-CSF-secreting adrenal carcinoma with rhabdoid-like differentiation causing leukocytosis Journal Article
| Authors: | Lou, E.; Goodwin, J.; Howell, D. N.; Hicks, J.; Brett Caram, L. |
| Article Title: | A G-CSF-secreting adrenal carcinoma with rhabdoid-like differentiation causing leukocytosis |
| Abstract: | Background: A 57-year-old African American man presented to a tertiary care center with a 6-month history of fatigue and worsening abdominal pain. He had lost 9.1 kg in weight in the 3 months leading up to presentation, and described subjective fevers and night sweats for 1 month with a nonproductive cough and blurred vision for several weeks before presentation. He had chronic renal insufficiency, sleep apnea, hypertension, and peripheral vascular disease. Investigations: Physical examination, complete blood count, peripheral blood smear, leukocyte alkaline phosphatase score, bone marrow biopsy, CT of the chest, abdomen, and pelvis, MRI of the abdomen and pelvis, measurement of plasma and urine metanephrines, 24 h urine testing for cortisol and 17-ketosteroids, measurement of serum granulocyte colony-stimulating factor (G-CSF) level, histopathologic examination and immunohistochemical staining of resected tumor. Diagnosis: G-CSF-secreting adrenal carcinoma with rhabdoid-like differentiation. Management: En bloc surgical resection of kidney, suprarenal mass and spleen was performed, followed by initiation of mitotane chemotherapy 3 months later. © 2009 Macmillan Publishers Limited. All Rights Reserved. |
| Keywords: | immunohistochemistry; adult; human tissue; middle aged; prednisone; fatigue; histopathology; splenectomy; case report; hypertension; nuclear magnetic resonance imaging; recurrent cancer; protein blood level; computer assisted tomography; nausea; vomiting; tumor differentiation; tumor markers, biological; weight reduction; pathology; tumor marker; nephrectomy; cell transformation, neoplastic; abdominal pain; adrenal cortex carcinoma; coughing; fever; alkaline phosphatase; malaise; death; bone marrow biopsy; cell transformation; laboratory test; peripheral vascular disease; physical examination; blood cell count; hydrocortisone; drug dose increase; urine level; granulocyte colony stimulating factor; metoclopramide; leukocytosis; granulocyte colony-stimulating factor; african american; chronic kidney failure; mitotane; adrenocortical carcinoma; 17 oxosteroid; metadrenalin; omeprazole; blood smear; blurred vision; catecholamine blood level; night sweat; sleep apnea syndrome; adrenal cortex tumor; rhabdoid tumor; secretion; adrenal cortex neoplasms |
| Journal Title: | Nature Reviews Urology |
| Volume: | 6 |
| Issue: | 7 |
| ISSN: | 1759-4812 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2009-07-01 |
| Start Page: | 392 |
| End Page: | 397 |
| Language: | English |
| DOI: | 10.1038/nrurol.2009.101 |
| PUBMED: | 19578356 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 30 November 2010" - "Source: Scopus" |
