Ga-68 DOTATOC PET/CT-guided biopsy and cryoablation with autoradiography of biopsy specimen for treatment of tumor-induced osteomalacia Journal Article
| Authors: | Maybody, M.; Grewal, R. K.; Healey, J. H.; Antonescu, C. R.; Fanchon, L.; Hwang, S.; Carrasquillo, J. A.; Kirov, A.; Farooki, A. |
| Article Title: | Ga-68 DOTATOC PET/CT-guided biopsy and cryoablation with autoradiography of biopsy specimen for treatment of tumor-induced osteomalacia |
| Abstract: | Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by small benign tumors of mesenchymal origin also known as phosphaturic mesenchymal tumors mixed connective tissue variant. Excellent prognosis is expected with eradication of the culprit tumor. These small tumors are notoriously difficult to localize with conventional imaging studies; this often leads to an extensive work up and prolonged morbidity. We report a patient with clinical diagnosis of TIO whose culprit tumor was localized with Ga-68 DOTATOC PET/CT and MRI. Biopsy and cryoablation were performed under Ga-68 DOTATOC PET/CT guidance. Autoradiography of the biopsy specimen was performed and showed in situ correlation between Ga-68 DOTATOC uptake and histopathology with millimeter resolution. |
| Keywords: | cryoablation; radiofrequency ablation; osteomalacia; dotatoc pet/ct; tumor-induced |
| Journal Title: | CardioVascular and Interventional Radiology |
| Volume: | 39 |
| Issue: | 9 |
| ISSN: | 0174-1551 |
| Publisher: | Springer |
| Date Published: | 2016-09-01 |
| Start Page: | 1352 |
| End Page: | 1357 |
| Language: | English |
| ACCESSION: | WOS:000380692600019 |
| DOI: | 10.1007/s00270-016-1350-1 |
| PROVIDER: | wos |
| PUBMED: | 27150801 |
| PMCID: | PMC5483397 |
| Notes: | Article -- Source: Wos |
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