The efficacy of multiparametric magnetic resonance imaging and magnetic resonance imaging targeted biopsy in risk classification for patients with prostate cancer on active surveillance Journal Article

   

Authors:	Recabal, P.; Assel, M.; Sjoberg, D. D.; Lee, D.; Laudone, V. P.; Touijer, K.; Eastham, J. A.; Vargas, H. A.; Coleman, J.; Ehdaie, B.
Article Title:	The efficacy of multiparametric magnetic resonance imaging and magnetic resonance imaging targeted biopsy in risk classification for patients with prostate cancer on active surveillance
Abstract:	Purpose We determined whether multiparametric magnetic resonance imaging targeted biopsies may replace systematic biopsies to detect higher grade prostate cancer (Gleason score 7 or greater) and whether biopsy may be avoided based on multiparametric magnetic resonance imaging among men with Gleason 3+3 prostate cancer on active surveillance. Materials and Methods We identified men with previously diagnosed Gleason score 3+3 prostate cancer on active surveillance who underwent multiparametric magnetic resonance imaging and a followup prostate biopsy. Suspicion for higher grade cancer was scored on a standardized 5-point scale. All patients underwent a systematic biopsy. Patients with multiparametric magnetic resonance imaging regions of interest also underwent magnetic resonance imaging targeted biopsy. The detection rate of higher grade cancer was estimated for different multiparametric magnetic resonance imaging scores with the 3 biopsy strategies of systematic, magnetic resonance imaging targeted and combined. Results Of 206 consecutive men on active surveillance 135 (66%) had a multiparametric magnetic resonance imaging region of interest. Overall, higher grade cancer was detected in 72 (35%) men. A higher multiparametric magnetic resonance imaging score was associated with an increased probability of detecting higher grade cancer (Wilcoxon-type trend test p <0.0001). Magnetic resonance imaging targeted biopsy detected higher grade cancer in 23% of men. Magnetic resonance imaging targeted biopsy alone missed higher grade cancers in 17%, 12% and 10% of patients with multiparametric magnetic resonance imaging scores of 3, 4 and 5, respectively. Conclusions Magnetic resonance imaging targeted biopsies increased the detection of higher grade cancer among men on active surveillance compared to systematic biopsy alone. However, a clinically relevant proportion of higher grade cancer was detected using only systematic biopsy. Despite the improved detection of disease progression using magnetic resonance imaging targeted biopsy, systematic biopsy cannot be excluded as part of surveillance for men with low risk prostate cancer. © 2016 American Urological Association Education and Research, Inc.
Keywords:	magnetic resonance imaging; prostatic neoplasms; watchful waiting; image-guided biopsy
Journal Title:	Journal of Urology
Volume:	196
Issue:	2
ISSN:	0022-5347
Publisher:	Elsevier Science, Inc.
Date Published:	2016-01-01
Start Page:	374
End Page:	380
Language:	English
DOI:	10.1016/j.juro.2016.02.084
PROVIDER:	scopus
PUBMED:	26920465
PMCID:	PMC5540367
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979649417&partnerID=40&md5=79c70f8372f7fd10cbc4b494b16fdfb0
Notes:	Article -- Export Date: 1 September 2016 -- Source: Scopus

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