Fully automated synthesis of [18F]fluoro-dihydrotestosterone ([18F]FDHT) using the FlexLab module Journal Article
| Authors: | Ackermann, U.; Lewis, J. S.; Young, K.; Morris, M. J.; Weickhardt, A.; Davis, I. D.; Scott, A. M. |
| Article Title: | Fully automated synthesis of [18F]fluoro-dihydrotestosterone ([18F]FDHT) using the FlexLab module |
| Abstract: | Imaging of androgen receptor expression in prostate cancer using F-18 FDHT is becoming increasingly popular. With the radiolabelling precursor now commercially available, developing a fully automated synthesis of [18F] FDHT is important. We have fully automated the synthesis of F-18 FDHT using the iPhase FlexLab module using only commercially available components. Total synthesis time was 90 min, radiochemical yields were 25-33% (n = 11). Radiochemical purity of the final formulation was > 99% and specific activity was > 18.5 GBq/µmol for all batches. This method can be up-scaled as desired, thus making it possible to study multiple patients in a day. Furthermore, our procedure uses 4 mg of precursor only and is therefore cost-effective. The synthesis has now been validated at Austin Health and is currently used for [18F]FDHT studies in patients. We believe that this method can easily adapted by other modules to further widen the availability of [18F]FDHT. Copyright © 2016 John Wiley & Sons, Ltd. |
| Journal Title: | Journal of Labelled Compounds and Radiopharmaceuticals |
| Volume: | 59 |
| Issue: | 10 |
| ISSN: | 0362-4803 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2016-08-01 |
| Start Page: | 424 |
| End Page: | 428 |
| Language: | English |
| DOI: | 10.1002/jlcr.3417 |
| PUBMED: | 27378195 |
| PROVIDER: | scopus |
| PMCID: | PMC4990449 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 September 2016 -- Source: Scopus |
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