Metastatic solid tumors to the jaw and oral soft tissue: A retrospective clinical analysis of 44 patients from a single institution Journal Article


Authors: Owosho, A. A.; Xu, B.; Kadempour, A.; Yom, S. K.; Randazzo, J.; Ghossein, R. A.; Huryn, J. M.; Estilo, C. L.
Article Title: Metastatic solid tumors to the jaw and oral soft tissue: A retrospective clinical analysis of 44 patients from a single institution
Abstract: Purpose Metastatic solid tumors to the oral cavity are rare, frequently indicative of an end-stage disease process, and associated with poor survival rates. We performed a 20-year retrospective clinical analysis of our institution's cases of solid metastases to the oral cavity, and investigated these patients’ clinical outcomes. Material and methods A retrospective study of patients with metastatic solid tumors to the oral cavity over a 20-year period (October 1996 to September 2015) was conducted at Memorial Sloan Kettering Cancer Center. Patients were selected if they had a histopathologically confirmed diagnosis. Demographic, pathologic, and clinical information were reviewed to identify patient outcomes. Results A total of 44 patients with metastatic non-melanocytic non-hematopoietic tumor to the oral cavity were identified: 24 males and 20 females (39 adults and 5 children) with a mean age of 54.3 years. In all, 24 cases involved the jaw and 20 cases involved the oral soft tissue. Eight patients (18.2%) had oral cavity metastases as the first indication of an occult malignancy. In adult patients, the common primary sites were the lungs (n = 9, 20%), kidney (n = 7, 16%), breast (n = 5, 11%), and colon (n = 4, 9%); and in pediatric patients the adrenal gland (3/5) was the most common site. Of the adult patients, 33 (84.6%) died of disease. From the time of metastasis diagnosis, patients with jaw metastases had a median and mean survival of 12 months and 27.7 months, respectively. In comparison, patients with oral soft tissue metastases had a median survival time of 5 months, and mean of 8 months. One pediatric patient (20%) died of disease 8 months after metastasis diagnosis. Conclusion Metastatic solid tumors to the oral cavity can be the first sign of a malignancy. Pediatric patients with oral cavity metastases have a better prognosis compared to adult patients. In this series, adults with oral soft tissue involvement had shorter survival times compared to patients with jaw involvement. © 2016 European Association for Cranio-Maxillo-Facial Surgery
Keywords: metastases; gingiva; mandible; jaw; metastatic tumor; oral soft tissue
Journal Title: Journal of Cranio-Maxillofacial Surgery
Volume: 44
Issue: 8
ISSN: 1010-5182
Publisher: Elsevier Inc.  
Date Published: 2016-08-01
Start Page: 1047
End Page: 1053
Language: English
DOI: 10.1016/j.jcms.2016.05.013
PROVIDER: scopus
PUBMED: 27270028
PMCID: PMC5279458
DOI/URL:
Notes: Article -- Export Date: 1 September 2016 -- Source: Scopus
Altmetric
Citation Impact
MSK Authors
  1. Joseph M Huryn
    94 Huryn
  2. Ronald A Ghossein
    402 Ghossein
  3. Cherry Estilo
    77 Estilo
  4. SaeHee Kim Yom
    33 Yom
  5. Bin   Xu
    159 Xu
  6. Adepitan Adedamola Owosho
    29 Owosho