Phase Ib study of enzalutamide in combination with docetaxel in men with metastatic castration-resistant prostate cancer Journal Article


Authors: Morris, M. J.; Rathkopf, D. E.; Novotny, W.; Gibbons, J. A.; Peterson, A. C.; Khondker, Z.; Ouatas, T.; Scher, H. I.; Fleming, M. T.
Article Title: Phase Ib study of enzalutamide in combination with docetaxel in men with metastatic castration-resistant prostate cancer
Abstract: Purpose: Preclinical evidence suggests that both docetaxel and enzalutamide target androgen receptor translocation and signaling. This phase Ib study assessed the safety, tolerability, and pharmacokinetics of docetaxel when administered with enzalutamide as first-line systemic chemotherapy in men with metastatic castration-resistant prostate cancer (mCRPC). Experimental Methods: Docetaxel-naïve patients received 21-day cycles of docetaxel (75 mg/m2 ). Enzalutamide (160 mg/day) was administered daily starting on day 2 of cycle 1. Patients were allowed to stop and restart docetaxel at any time following cycle 2. Treatment continued indefinitely until unacceptable toxicity or discontinuation due to investigator or patient preference. Results: A total of 22 patients received docetaxel, of whom 21 also received enzalutamide. Docetaxel was administered for a median of 5.0 cycles and enzalutamide for a median of 12.0 months. With concomitant treatment, geometric mean docetaxel exposure decreased by 11.8%, whereas peak concentrations decreased by 3.7% relative to docetaxel alone. The most common toxicities observed during the period of concomitant therapy were neutropenia (86.4%) and fatigue (77.3%). Common toxicities observed with post-docetaxel enzalutamide were constipation (23.8%), decreased appetite (19.0%), fatigue (19.0%), and musculoskeletal pain (19.0%). Treatment with enzalutamide and docetaxel resulted in prostate-specific antigen decreases in almost all patients based on exploratory analysis of available baseline and on-study prostate-specific antigen data. Conclusions: The combination of docetaxel and enzalutamide is feasible, although higher rates of neutropenia and neutropenic fever than anticipated were observed. Reductions in docetaxel exposure with enzalutamide coadministration were not considered clinically meaningful. This combination warrants further study in a larger mCRPC population. ©2016 AACR.
Journal Title: Clinical Cancer Research
Volume: 22
Issue: 15
ISSN: 1078-0432
Publisher: American Association for Cancer Research  
Date Published: 2016-08-01
Start Page: 3774
End Page: 3781
Language: English
DOI: 10.1158/1078-0432.ccr-15-2638
PROVIDER: scopus
PUBMED: 26858312
PMCID: PMC5468167
DOI/URL:
Notes: Article -- Export Date: 1 September 2016 -- Source: Scopus
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  1. Michael Morris
    578 Morris
  2. Dana Elizabeth Rathkopf
    273 Rathkopf
  3. Howard Scher
    1130 Scher