Prognostic impact of tumor microenvironment in diffuse large B-cell lymphoma uniformly treated with R-CHOP chemotherapy Journal Article
| Authors: | Gomez-Gelvez, J. C.; Salama, M. E.; Perkins, S. L.; Leavitt, M.; Inamdar, K. V. |
| Article Title: | Prognostic impact of tumor microenvironment in diffuse large B-cell lymphoma uniformly treated with R-CHOP chemotherapy |
| Abstract: | Objectives: We evaluated the prognostic impact of cell-oforigin classification as well as intratumoral regulatory T cells (Tregs), macrophages, and microvessel density (MVD) on 115 patients (74 in the training set and 41 in the validation set) diagnosed with de novo diffuse large B-cell lymphoma (DLBCL) and uniformly treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy. Methods: The prognostic impact of Tregs, macrophages, and MVD was evaluated using FOXP3, CD68, and CD34 immunohistochemical stains, respectively. In addition, we designed a scoring system where 1 point was awarded per each adverse prognostic factor, including non-germinal center B-cell-like subtype, FOXP3 17% or more, CD68 less than 2%, and MVDless than 800 vessels/mm2. Results: Although only MVD was statistically significant on multivariate analysis, the scoring system significantly segregated patients into low- and high-risk groups. Patients having two or more adverse prognostic factors (high-risk group) demonstrated significantly worse event-free and progression- free survivals in the training set and event-free survival in the validation set. Conclusions: The concomitant evaluation of cell of origin along with tumor microenvironment components identifies patients with DLBCL treated with R-CHOP chemotherapy portraying a worse prognosis. © American Society for Clinical Pathology, 2016. |
| Keywords: | macrophages; microvasculature; diffuse large b-cell lymphoma; tumor microenvironment; prognostic impact; regulatory t lymphocytes |
| Journal Title: | American Journal of Clinical Pathology |
| Volume: | 145 |
| Issue: | 4 |
| ISSN: | 0002-9173 |
| Publisher: | Oxford University Press |
| Date Published: | 2016-04-01 |
| Start Page: | 514 |
| End Page: | 523 |
| Language: | English |
| DOI: | 10.1093/ajcp/aqw034 |
| PROVIDER: | scopus |
| PUBMED: | 27124945 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 September 2016 -- Source: Scopus |
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