Dianion equivalents corresponding to the polypropionate domain of epothilone B Journal Article
| Authors: | Harris, C. R.; Kuduk, S. D.; Savin, K.; Balog, A.; Danishefsky, S. J. |
| Article Title: | Dianion equivalents corresponding to the polypropionate domain of epothilone B |
| Abstract: | A modified synthesis of the polypropionate portion of epothilone, which utilizes a novel, diastereoselective aldol reaction of (S)-2-methyl-4- pentenal (4) and the Z-enolate of the tricarbonyl species (3) is reported. |
| Keywords: | chemical analysis; cytotoxicity; drug potency; drug synthesis; maximum allowable concentration; reaction analysis; stereochemistry; epothilone b; article; aldol; methyl enol ether; polypropionate |
| Journal Title: | Tetrahedron Letters |
| Volume: | 40 |
| Issue: | 12 |
| ISSN: | 0040-4039 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 1999-03-19 |
| Start Page: | 2263 |
| End Page: | 2266 |
| Language: | English |
| DOI: | 10.1016/s0040-4039(99)00221-x |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
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