Strategies to eradicate minimal residual disease in small cell lung cancer: High-dose chemotherapy with autologous bone marrow transplantation, matrix metalloproteinase inhibitors, and BEC2 plus BCG vaccination Journal Article
| Authors: | Krug, L. M.; Grant, S. C.; Miller, V. A.; Ng, K. K.; Kris, M. G. |
| Article Title: | Strategies to eradicate minimal residual disease in small cell lung cancer: High-dose chemotherapy with autologous bone marrow transplantation, matrix metalloproteinase inhibitors, and BEC2 plus BCG vaccination |
| Abstract: | In the last 25 years, treatment for small cell lung cancer (SCLC) has improved with advances in chemotherapy and radiotherapy. Standard chemotherapy regimens can yield 80% to 90% response rates and some cures when combined with thoracic irradiation in limited-stage patients. Nonetheless, small cell lung cancer has a high relapse rate due to drug resistance; this has resulted in poor survival for most patients. Attacking this problem requires a unique approach to eliminate resistant disease remaining after induction therapy. This review will focus on three potential strategies: high-dose chemotherapy with autologous bone marrow transplantation, matrix metalloproteinase inhibitors, and BEC2 plus BCG vaccination. |
| Keywords: | unclassified drug; cancer recurrence; cisplatin; doxorubicin; drug efficacy; multimodality cancer therapy; methotrexate; drug megadose; antineoplastic agent; bcg vaccine; cancer immunotherapy; etoposide; thrombocytopenia; antineoplastic combined chemotherapy protocols; lung neoplasms; myalgia; cyclophosphamide; melphalan; vincristine; monoclonal antibody; arthralgia; rash; lung small cell cancer; antibodies, monoclonal; neoplasm, residual; enzyme inhibitors; bone marrow transplantation; clinical trials; marimastat; matrix metalloproteinases; prinomastat; carcinoma, small cell; matrix metalloproteinase inhibitor; autologous bone marrow transplantation; gangliosides; humans; human; priority journal; article; batimastat; 4 [4,4 (chlorophenyl)phenyl] 4 oxo (phenylthiomethyl)butanoic acid; cgs 27023a |
| Journal Title: | Seminars in Oncology |
| Volume: | 26 |
| Issue: | 5 Suppl. 15 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1999-10-01 |
| Start Page: | 55 |
| End Page: | 61 |
| Language: | English |
| PUBMED: | 10566613 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
