Sentinel lymph node biopsy after percutaneous diagnosis of nonpalpable breast cancer Journal Article


Authors: Liberman, L.; Cody, H. S. 3rd; Hill, A. D. K.; Rosen, P. P.; Yeh, S. D. J.; Akhurst, T.; Morris, E. A.; Abramson, A. F.; Borgen, P. I.; Dershaw, D. D.
Article Title: Sentinel lymph node biopsy after percutaneous diagnosis of nonpalpable breast cancer
Abstract: PURPOSE: To determine the technical success rate of sentinel lymph node biopsy in women with nonpalpable infiltrating breast cancer diagnosed by using percutaneous core biopsy and to determine the frequency with which sentinel lymph node biopsy obviated axillary dissection. MATERIALS AND METHODS: Retrospective review revealed 33 women who underwent sentinel node biopsy after percutaneous core biopsy diagnosis of nonpalpable infiltrating breast cancer. Sentinel nodes were identified with radioisotope and blue dye; the procedure was technically successful if sentinel nodes were found at surgery. All sentinel nodes were excised. Axillary dissection was performed if tumor was present in sentinel nodes. RESULTS: Sentinel nodes were found at surgery in 30 women (91%). Sentinel nodes were identified with both radioisotope and blue dye in 22 (73%) of these women, with only radioisotope in six (20%), and with only blue dye in two (7%). Sentinel nodes were found in 12 (80%) of 15 women in the first half of the study versus all 18 (100%) women in the second half (P = .08). Sentinel nodes were free of tumor in 23 (77%) of 30 women. In six (86%) of seven women with tumor in sentinel nodes, the sentinel nodes were the only nodes with tumor. CONCLUSION: Sentinel node biopsy was successful in 30 women (91%) with nonpalpable infiltrating carcinoma diagnosed with percutaneous core biopsy and obviated axillary dissection in 23 women (70%). Using both radioisotope and blue dye may increase the success rate. A learning curve exists, and success improves with experience.
Keywords: adult; clinical article; aged; aged, 80 and over; middle aged; retrospective studies; lymph node metastasis; cancer diagnosis; lymph nodes; lymphatic metastasis; lymph node excision; radiopharmaceuticals; technetium tc 99m sulfur colloid; breast cancer; echomammography; diagnostic imaging; breast neoplasms; biopsy; ultrasound; biopsy, needle; needle biopsy; radioisotope; lymph node biopsy; breast biopsy; intravenous drug administration; stereotaxic surgery; technetium sulfur colloid tc 99m; albumin tc 99m; coloring agents; humans; human; female; priority journal; article; breast, biopsy; breast neoplasms, surgery; breast neoplasms, therapy; lymphatic system, biopsy; lymphatic system, neoplasms
Journal Title: Radiology
Volume: 211
Issue: 3
ISSN: 0033-8419
Publisher: Radiological Society of North America, Inc.  
Date Published: 1999-06-01
Start Page: 835
End Page: 844
Language: English
PUBMED: 10352613
PROVIDER: scopus
DOI: 10.1148/radiology.211.3.r99jn28835
DOI/URL:
Notes: Article -- Export Date: 16 August 2016 -- Source: Scopus
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MSK Authors
  1. Samuel D J Yeh
    107 Yeh
  2. D David Dershaw
    223 Dershaw
  3. Laura Liberman
    176 Liberman
  4. Hiram S Cody III
    242 Cody
  5. Arnold D Hill
    16 Hill
  6. Elizabeth A Morris
    336 Morris
  7. Patrick I Borgen
    253 Borgen
  8. Timothy J Akhurst
    139 Akhurst
  9. Paul P Rosen
    201 Rosen