Retention of heroin and morphine-6β-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1 Journal Article
| Authors: | Schuller, A. G. P.; King, M. A.; Zhang, J.; Bolan, E.; Pan, Y. X.; Morgan, D. J.; Chang, A.; Czick, M. E.; Unterwald, E. M.; Pasternak, G. W.; Pintar, J. E. |
| Article Title: | Retention of heroin and morphine-6β-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1 |
| Abstract: | Morphine produces analgesia by activating mu opioid receptors encoded by the MOR-1 gene. Although morphine-6β-glucuronide (M6G), heroin and 6- acetylmorphine also are considered mu opioids, recent evidence suggests that they act through a distinct receptor mechanism. We examined this question in knockout mice containing disruptions of either the first or second coding exon of MOR-1. Mice homozygous for either MOR-1 mutation were insensitive to morphine. Heroin, 6-acetylmorphine and M6G still elicited analgesia in the exon-1 MOR-1 mutant, which also showed specific M6G binding, whereas M6G and 6-acetylmorphine were inactive in the exon-2 MOR-1 mutant. These results provide genetic evidence for a unique receptor site for M6G and heroin analgesia. |
| Keywords: | protein expression; exon; exons; nonhuman; animal cell; mouse; animals; mice; mice, knockout; pain; transcription, genetic; drug resistance; mice, inbred c57bl; drug receptor binding; morphine; analgesics, opioid; analgesia; receptors, opioid, mu; diamorphine; morphine 6 glucuronide; heroin; morphine derivatives; priority journal; article |
| Journal Title: | Nature Neuroscience |
| Volume: | 2 |
| Issue: | 2 |
| ISSN: | 1097-6256 |
| Publisher: | Nature Publishing Group |
| Date Published: | 1999-02-01 |
| Start Page: | 151 |
| End Page: | 156 |
| Language: | English |
| DOI: | 10.1038/5706 |
| PUBMED: | 10195199 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
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