Upper tract recurrences following radical cystectomy: An analysis of prognostic factors, recurrence pattern and stage at presentation Journal Article
| Authors: | Balaji, K. C.; McGuire, M.; Grotas, J.; Grimaldi, G.; Russo, P. |
| Article Title: | Upper tract recurrences following radical cystectomy: An analysis of prognostic factors, recurrence pattern and stage at presentation |
| Abstract: | Purpose: We study the incidence and pattern of upper tract recurrences following radical cystectomy for bladder cancer, and analyze the prognostic factors. Materials and Methods: A retrospective study was performed on 529 patients who underwent radical cystectomy and urinary diversion at Memorial Sloan-Kettering Cancer Center between July 1989 and June 1997. Data related to upper tract recurrence were analyzed. Results: Of the 529 patients 16 (3%) had upper tract recurrence. Median followup was 16.9 months for the entire group and 49.1 months for patients with upper tract recurrence, with a median time to recurrence of 37.2 months. Of 12 upper tract recurrences 7 (58%) were locally advanced at surgery (p3a or greater with or without lymph node metastasis) and 5 of 16 patients with recurrence (31.3%) had bilateral tumors (2 synchronous and 3 metachronous). Overall survival from the time of diagnosis of upper tract recurrence after radical cystectomy was poor, with a median of 10 months (confidence interval 1 to 19). Conclusions: The incidence of upper tract recurrence following radical cystectomy is low (3%). However, the incidence of bilateral tumors (31.3%) and locally advanced stage at the time of operation (58%) is higher than expected for upper tract tumors in the general population. Survival of patients with upper tract recurrence is poor, with a median of 10 months. |
| Keywords: | adult; cancer survival; clinical article; aged; cancer recurrence; cancer staging; follow up; recurrence; bladder cancer; cystectomy; urinary tract cancer; carcinoma; transitional cell carcinoma; transitional cell; urinary tract; prognosis; human; male; female; priority journal; article |
| Journal Title: | Journal of Urology |
| Volume: | 162 |
| Issue: | 5 |
| ISSN: | 0022-5347 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1999-11-01 |
| Start Page: | 1603 |
| End Page: | 1606 |
| Language: | English |
| DOI: | 10.1016/s0022-5347(05)68176-1 |
| PUBMED: | 10524877 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
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