Upper tract recurrences following radical cystectomy: An analysis of prognostic factors, recurrence pattern and stage at presentation Journal Article


Authors: Balaji, K. C.; McGuire, M.; Grotas, J.; Grimaldi, G.; Russo, P.
Article Title: Upper tract recurrences following radical cystectomy: An analysis of prognostic factors, recurrence pattern and stage at presentation
Abstract: Purpose: We study the incidence and pattern of upper tract recurrences following radical cystectomy for bladder cancer, and analyze the prognostic factors. Materials and Methods: A retrospective study was performed on 529 patients who underwent radical cystectomy and urinary diversion at Memorial Sloan-Kettering Cancer Center between July 1989 and June 1997. Data related to upper tract recurrence were analyzed. Results: Of the 529 patients 16 (3%) had upper tract recurrence. Median followup was 16.9 months for the entire group and 49.1 months for patients with upper tract recurrence, with a median time to recurrence of 37.2 months. Of 12 upper tract recurrences 7 (58%) were locally advanced at surgery (p3a or greater with or without lymph node metastasis) and 5 of 16 patients with recurrence (31.3%) had bilateral tumors (2 synchronous and 3 metachronous). Overall survival from the time of diagnosis of upper tract recurrence after radical cystectomy was poor, with a median of 10 months (confidence interval 1 to 19). Conclusions: The incidence of upper tract recurrence following radical cystectomy is low (3%). However, the incidence of bilateral tumors (31.3%) and locally advanced stage at the time of operation (58%) is higher than expected for upper tract tumors in the general population. Survival of patients with upper tract recurrence is poor, with a median of 10 months.
Keywords: adult; cancer survival; clinical article; aged; cancer recurrence; cancer staging; follow up; recurrence; bladder cancer; cystectomy; urinary tract cancer; carcinoma; transitional cell carcinoma; transitional cell; urinary tract; prognosis; human; male; female; priority journal; article
Journal Title: Journal of Urology
Volume: 162
Issue: 5
ISSN: 0022-5347
Publisher: Elsevier Science, Inc.  
Date Published: 1999-11-01
Start Page: 1603
End Page: 1606
Language: English
DOI: 10.1016/s0022-5347(05)68176-1
PUBMED: 10524877
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 16 August 2016 -- Source: Scopus
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MSK Authors
  1. Paul Russo
    457 Russo
  2. K C Balaji
    7 Balaji