Effect of neoadjuvant hormonal therapy on prostatic intraepithelial neoplasia and its prognostic significance Journal Article


Authors: Balaji, K. C.; Rabbani, F.; Tsai, H.; Bastar, A.; Fair, W. R.
Article Title: Effect of neoadjuvant hormonal therapy on prostatic intraepithelial neoplasia and its prognostic significance
Abstract: Purpose: We studied the effect of neoadjuvant hormonal therapy on prostatic intraepithelial neoplasia in patients undergoing radical prostatectomy and assessed the effect of prostatic intraepithelial neoplasia on disease recurrence as measured by serum prostate specific antigen (PSA). Materials and Methods: A total of 278 patients with clinically localized prostate cancer were included in phase II and III studies evaluating radical prostatectomy alone versus radical prostatectomy following neoadjuvant hormonal therapy at Memorial Sloan-Kettering Cancer Center between October 1991 and August 1996. Patient data related to prostatic intraepithelial neoplasia were analyzed. Results: Of 275 evaluable patients 145 (52.7%) had prostatic intraepithelial neoplasia. Of 50 patients treated with neoadjuvant hormonal therapy (hormone group) 22 (44%) had a lower incidence of prostatic intraepithelial neoplasia compared to 69 of 80 controls (86.3%) (chi-square test p <0.0001). Of 262 patients (95.3%) with followup PSA 44 (16.8%) had PSA recurrence at a median followup of 32 months, with a median time to recurrence of 30 months. PSA recurrence was noted in 23 of 145 patients with compared to 21 of 130 without prostatic intraepithelial neoplasia (chi-square test p = 0.95), and did not significantly differ between the hormone group (25 of 142, 17.6%) and controls (19 of 130, 14.6%) (chi-square test p = 0.45). Conclusions: While patients treated with neoadjuvant hormonal therapy had significantly lower incidence of prostatic intraepithelial neoplasia, neither prostatic intraepithelial neoplasia nor neoadjuvant hormonal therapy significantly affected PSA recurrence at a median followup of 32 months.
Keywords: controlled study; major clinical study; cancer recurrence; cancer adjuvant therapy; chemotherapy, adjuvant; follow up; follow-up studies; prostate specific antigen; neoplasm recurrence, local; recurrence; prostate cancer; prostate-specific antigen; prostatic neoplasms; prostate; prostatectomy; prostate epithelium; multivariate analysis; prostatic intraepithelial neoplasia; hormonal therapy; flutamide; antineoplastic agents, hormonal; hormone; leuprolide; hormones; humans; prognosis; human; male; priority journal; article
Journal Title: Journal of Urology
Volume: 162
Issue: 3 Part 1
ISSN: 0022-5347
Publisher: Elsevier Science, Inc.  
Date Published: 1999-09-01
Start Page: 753
End Page: 757
Language: English
DOI: 10.1097/00005392-199909010-00035
PUBMED: 10458359
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 16 August 2016 -- Source: Scopus
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MSK Authors
  1. Farhang Rabbani
    82 Rabbani
  2. Harold Tsai
    4 Tsai
  3. William R Fair
    199 Fair
  4. K C Balaji
    7 Balaji
  5. Andrew L Bastar
    9 Bastar