Is transurethral biopsy of the bladder necessary after 3 months to evaluate response to bacillus Calmette-Guerin therapy? Journal Article

  


Authors: Dalbagni, G.; Rechtschaffen, T.; Herr, H. W.
Article Title: Is transurethral biopsy of the bladder necessary after 3 months to evaluate response to bacillus Calmette-Guerin therapy?
Abstract: Purpose: We assessed the need for transurethral biopsy of the bladder at the 3-month evaluation in patients who have received intravesical bacillus Calmette-Guerin (BCG). B Materials and Methods: A total of 81 patients collectively received 83, 6-week courses of BCG between 1995 and 1997, and underwent transurethral bladder biopsies 3 months after initiation of immunotherapy. The pretreatment and posttreatment bladder biopsy results, urinary cytology and posttreatment cystoscopic findings were correlated. Results: Transitional cell carcinoma was demonstrated in 5 of 11 patients with erythematous bladder mucosa and a positive cytology compared to none of 37 with an erythematous lesion and a negative cytology. Of 12 patients with a papillary lesion on cystoscopy and a positive biopsy 10 had a negative cytology, and only 1 of 13 patients with a negative cystoscopy had a positive biopsy. Conclusions: Bladder biopsy is not necessary in patients 3 months after receiving BCG who have a normal office cystoscopy or an erythematous bladder and normal urine cytology.
Keywords: adult; human tissue; treatment outcome; aged; aged, 80 and over; middle aged; human cell; major clinical study; bcg vaccine; cancer immunotherapy; diagnostic approach route; urinary bladder neoplasms; biopsy; time factors; carcinoma; cystoscopy; carcinoma, transitional cell; adjuvants, immunologic; transitional cell carcinoma; urethra; intravesical drug administration; urine cytology; bladder biopsy; bladder mucosa; bladder neoplasm; humans; human; male; female; priority journal; article
Journal Title: Journal of Urology
Volume: 162
Issue: 3 Part 1
ISSN: 0022-5347
Publisher: Elsevier Science, Inc.  
Date Published: 1999-09-01
Start Page: 708
End Page: 709
Language: English
DOI: 10.1097/00005392-199909010-00020
PUBMED: 10458348
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032832557&partnerID=40&md5=26593ec4d84971ff9b45ddf41fad7e97
Notes: Article -- Export Date: 16 August 2016 -- Source: Scopus
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MSK Authors
  1. Guido Dalbagni
    325 Dalbagni
  2. Harry W Herr
    594 Herr
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