Stitching together RNA tertiary architectures Journal Article
| Authors: | Hermann, T.; Patel, D. J. |
| Article Title: | Stitching together RNA tertiary architectures |
| Abstract: | The powerful explanatory paradigm of molecular biology requiring form to co-evolve with function has again been proven successful when, over the recent two decades, a wealth of biological functions have been uncovered for RNA. Previously considered as a mere mediator of the genetic code, RNA is now acknowledged as a key player in a wide variety of cellular processes. Along with the discovery of novel biological functions of RNA molecules, a number of RNA three-dimensional structures have been solved which beautifully demonstrate the molecular adaptability which allows RNA to participate as a key player in these functions. A distinct repertoire of molecular motifs provides a basis for the assembly of complex RNA tertiary architectures. |
| Keywords: | nonhuman; intron; rna; nuclear magnetic resonance spectroscopy; base pairing; crystal structure; hydrogen bond; hydrogen bonding; models, molecular; water; nucleic acid conformation; molecular biology; rna structure; molecular model; metals; base pair mismatch; metal ion; ribozyme; rna conformation; cations; priority journal; article; metal ions and hydration; ribozymes and catalysis; rna folding and function; rna motifs; x-ray, nmr, and molecular modeling; tetrahymena thermophila |
| Journal Title: | Journal of Molecular Biology |
| Volume: | 294 |
| Issue: | 4 |
| ISSN: | 0022-2836 |
| Publisher: | Academic Press Inc., Elsevier Science |
| Date Published: | 1999-12-10 |
| Start Page: | 829 |
| End Page: | 849 |
| Language: | English |
| DOI: | 10.1006/jmbi.1999.3312 |
| PUBMED: | 10588890 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work