Efficacy of selective alpha-1 blocker therapy in the treatment of acute urinary symptoms during radiotherapy for localized prostate cancer Journal Article
| Authors: | Zelefsky, M. J.; Ginor, R. X.; Fuks, Z.; Leibel, S. A. |
| Article Title: | Efficacy of selective alpha-1 blocker therapy in the treatment of acute urinary symptoms during radiotherapy for localized prostate cancer |
| Abstract: | Purpose: To determine the efficacy of an alpha-1 adrenoreceptor blocking agent for acute urinary symptoms in patients treated with radiotherapy for localized prostate cancer. Methods and Materials: Between 1987 and 1995, 743 patients with clinically localized prostate cancer were treated with 3D-CRT. A total of 275 (37%) patients developed Grade 2 acute urinary symptoms as defined by the RTOG morbidity scoring system. Terazosin hydrochloride (THC), a selective alpha-1 adrenoceptor blocking agent, was given to 119 (43%) patients for treatment of their urinary symptoms, whereas nonsteroidal anti-inflammatory medications (NSAID) were administered to 71 patients (26%). Thirty-one patients (11%) were treated with other medications, and 54 (20%) did not seek pharmacologic intervention for their urinary symptoms. Patients were monitored weekly to assess changes in urinary urgency, frequency, and nocturia.Results: Treatment with THC resulted in a significant resolution of urinary symptoms in 79 of 119 patients (66%), while 26 (22%) had moderate improvement, and 14 (12%) had minimal to no response to this drug. In contrast, only 11 of 71 (16%) of the patients treated with NSAIDs experienced significant symptom relief, 20 (28%) had moderate improvement, and 40 (56%) had minimal to no response. The difference in the significant symptomatic improvement between THC and NSAID therapy (66% vs. 16%) was highly significant (p < 0.001). For patients treated with THC, a higher likelihood of significant symptom relief was observed in patients who did not receive neoadjuvant androgen ablation (p = 0.04) and in those who were younger than 65 years of age (p = 0.02). Conclusion: Alpha-1 selective adrenoceptor blocking agents are effective in ameliorating the acute urinary symptoms in patients receiving radiotherapy for localized prostate cancer. Although this was not a randomized prospective study, the data suggest that NSAIDs were less effective in relieving radiation-induced urinary symptoms. Copyright (C) 1999 Elsevier Science Inc. |
| Keywords: | aged; aged, 80 and over; middle aged; retrospective studies; major clinical study; drug efficacy; cancer radiotherapy; radiation injury; prostate cancer; prostatic neoplasms; ibuprofen; nonsteroid antiinflammatory agent; anti-inflammatory agents, non-steroidal; radiation injuries; prostate adenocarcinoma; radiotherapy, conformal; conformal radiotherapy; micturition disorder; nocturia; urination disorders; terazosin; oxybutynin; phenazopyridine; prazosin; adrenergic alpha-antagonists; humans; human; male; priority journal; article; urinary symptoms; alpha 1 adrenergic receptor blocking agent |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 45 |
| Issue: | 3 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1999-10-01 |
| Start Page: | 567 |
| End Page: | 570 |
| Language: | English |
| DOI: | 10.1016/s0360-3016(99)00232-1 |
| PUBMED: | 10524407 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work