Involvement of the Ink4a gene (p16 and p19arf) in murine tumorigenesis Journal Article
| Authors: | Orlow, I.; Rabbani, F.; Chin, L.; Pomerantz, J.; Ligeois, N.; Dudas, M.; Depinho, R.; Cordón-Cardó, C. |
| Article Title: | Involvement of the Ink4a gene (p16 and p19arf) in murine tumorigenesis |
| Abstract: | The INK4A and INK4B genes map to 9p21, with the INK4A gene encoding two products, p16 and p19ARF. Many neoplasms in which INK4A and INK4B genes are altered show deletions involving both genes. Mice carrying a targeted Ink4a deletion develop tumors at an early age. In the present study we examined the genetic alterations affecting the remaining Ink4a allele and the Ink4b gene in tumors arising in heterozygous Ink4a mice. We identified deletion of the remaining Ink4a allele in 7 of 18 (39%) tumors. We also observed deletion of the exon 1β in 3 cases, one of them presenting this deletion as a unique alteration. In conclusion, the deletion of the remaining Ink4a allele was the alteration most frequently observed, representing the inactivation of two proteins capable of arresting the cell cycle through different pathways that involve the tumor suppressors pRB and p53. |
| Keywords: | gene deletion; genetics; polymerase chain reaction; proteins; mouse; animal; mouse mutant; animals; mice; mice, knockout; gene targeting; cell cycle; genetic predisposition to disease; protein; pathology; heterozygote; physiology; tumor suppressor gene; dna; chemically induced disorder; dna, neoplasm; neoplasms, experimental; experimental neoplasm; cyclin-dependent kinase inhibitor p16; tumor suppressor protein p14arf; p16 gene; retinoblastoma protein; genetic predisposition; genes, p16; single strand conformation polymorphism; polymorphism, single-stranded conformational; protein p14arf; protein p16ink4a; article; murine tumorigenesis; p19arf gene |
| Journal Title: | International Journal of Oncology |
| Volume: | 15 |
| Issue: | 1 |
| ISSN: | 1019-6439 |
| Publisher: | Spandidos Publications |
| Date Published: | 1999-07-01 |
| Start Page: | 17 |
| End Page: | 24 |
| Language: | English |
| PUBMED: | 10375589 |
| PROVIDER: | scopus |
| DOI: | 10.3892/ijo.15.1.17 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
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84Rabbani -
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247Orlow -
53
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