| Abstract: |
Examination of the expression pattern of the winged-helix transcription factor BF-1 outside of the neural tube in mouse embryos suggests that BF-1 is restricted to a population of cells that gives rise to the ectodermal placodes and their derivatives. Within the sensory cranial nerve ganglia, the expression of BF-1 distinguishes cells that arise from the placodes from those derived from the neural crest. Expression of a lacZ transgene targeted to the BF-1 locus was used to follow the placodal lineage during mouse development. Analysis of placodal development in mice with a targeted deletion of BF-1 reveals that, although BF-1 is required for proliferation of the cells arising from the nasal placode, it is not required for the proliferation, survival, or both, of placode-derived cells in the sensory cranial nerve ganglia. |
| Keywords: |
gene deletion; dna-binding proteins; nonhuman; protein localization; cell proliferation; forkhead transcription factors; mouse; mammalia; animals; mice; embryo; animal experiment; nerve tissue proteins; gene locus; transcription factor; time factors; cell lineage; animalia; mice, transgenic; transcription factors; in situ hybridization; embryo, nonmammalian; gene expression regulation, developmental; brain development; transgene; cell movement; neural crest; rodentia; mice, inbred cba; neural tube; peripheral nervous system; cranial nerve; chick embryo; bf-1; ectoderm; gene expression system; priority journal; article; ectodermal placodes; head development; sensory cranial nerves; winged helix transcription factors; early growth response protein 2; ganglia, sensory
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