Long-term outcome of a Phase II study of BM transplants, partially depleted ex-vivo of CD5-positive and CD8-positive T-lymphocytes in unrelated and related donor 1 antigen mismatched recipients Journal Article
| Authors: | Gajewski, J. L.; Nimer, S.; Saliba, R. M.; Thomas, M.; Przepiorka, D.; Giralt, S.; von Besien, K.; Mehra, R.; Andersson, B.; Chan, K. W.; Ippoliti, C.; Warkinten, D.; Feigs, S.; Territo, M.; Schiller, G.; Lebkowski, J.; Moseley, A. M.; Lloyd, K.; von Hoeff, M.; Okarma, T.; Champlin, R. |
| Article Title: | Long-term outcome of a Phase II study of BM transplants, partially depleted ex-vivo of CD5-positive and CD8-positive T-lymphocytes in unrelated and related donor 1 antigen mismatched recipients |
| Abstract: | Background: Mismatched family donor and unrelated donor BM transplants are associated with a high risk of acute GvHD. While T-cell depletion is the best method to reduce risk of acute GvHD, there was a reluctance to use T-cell depletion in the mismatched setting because of increased risk of rejection and relapse. Partial T-cell depletion, by the panning of CDS and CD8 positive T cells may reduce complications related to GvHD -without compromising outcomes. Method: In a long-term follow-up of a Phase II study of partial T-cell depletion by panning for BM transplant, 32 recipients received transplants from a single-Ag (HLA A, B, or DR) mismatched family donor; or an HLA serologically-matched unrelated donor. Patients were studied for engraftment, GHD, relapse and survival. Results: 30 (94%) of the patients marrow engrafted. The cumulative risk of Grade 2-4 acute GvHD was 62 ± 9%; of Grade 3-4 GvHD, 11 ± 6%. The 4-year cumulative risk of relapse was 18 ± 8% and actuarial survival was 44 ± 9%. Discussion :Partial T-cell depletion had a low rate of severe acute GvHD without compromising engrafment or relapse risk. © 1999 ISHAGE. |
| Keywords: | adolescent; adult; child; treatment outcome; leukemia; clinical trial; follow up; methodology; follow-up studies; cd8+ t lymphocyte; cd8-positive t-lymphocytes; cytology; metabolism; bone marrow cells; phase 2 clinical trial; bone marrow; recurrence; biosynthesis; immunology; lymphoma; graft versus host reaction; recurrent disease; bone marrow cell; bone marrow transplantation; graft vs host disease; cd5 antigen; antigens, cd5; unrelated; histocompatibility; t-cell depletion; humans; human; male; female; article |
| Journal Title: | Cytotherapy |
| Volume: | 1 |
| Issue: | 5 |
| ISSN: | 1465-3249 |
| Publisher: | Elsevier Science Ltd. |
| Date Published: | 1999-01-01 |
| Start Page: | 401 |
| End Page: | 407 |
| Language: | English |
| PUBMED: | 20426540 |
| PROVIDER: | scopus |
| DOI: | 10.1080/0032472031000141284 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
