Prostate-specific membrane antigen is produced in tumor-associated neovasculature Journal Article
| Authors: | Chang, S. S.; O'Keefe, D. S.; Bacich, D. J.; Reuter, V. E.; Heston, W. D. W.; Gaudin, P. B. |
| Article Title: | Prostate-specific membrane antigen is produced in tumor-associated neovasculature |
| Abstract: | Prostate-specific membrane antigen (PSMA), a type II transmembrane protein, was originally thought to be strictly expressed in prostatic tissue, but recent studies have demonstrated PSMA protein expression in nonprostatic tumor neovasculature as well. Using immunohistochemistry, reverse transcription-PCR assays, and in situ hybridization, we have demonstrated PSMA mRNA transcripts and protein expression in the endothelium of tumor- associated neovasculature of multiple nonprostatic solid malignancies. In addition, we found no PSMA mRNA or protein expression in the vascular endothelial cells of corresponding benign tissue examples. Our findings expand the possible therapeutic role of PSMA and establish it as a unique biomarker specifically produced and expressed by tumor-associated neovasculature but not produced or expressed by normal vessels. |
| Keywords: | immunohistochemistry; human tissue; protein expression; neoplasms; biological marker; prostate specific antigen; reverse transcription polymerase chain reaction; in situ hybridization; membrane antigen; antigens, neoplasm; reverse transcriptase polymerase chain reaction; rna, messenger; tumor vascularization; neovascularization (pathology); glutamate carboxypeptidase ii; antigens, surface; humans; human; male; female; priority journal; article; carboxypeptidases |
| Journal Title: | Clinical Cancer Research |
| Volume: | 5 |
| Issue: | 10 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 1999-10-01 |
| Start Page: | 2674 |
| End Page: | 2681 |
| Language: | English |
| PUBMED: | 10537328 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
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