Small cell carcinoma of the ureter arising in an adult polycystic kidney disease: A case report Journal Article

  


Authors: Gupta, M.; Xia, J.; Priminger, B.; Varkey, J.; Luke, S.
Article Title: Small cell carcinoma of the ureter arising in an adult polycystic kidney disease: A case report
Abstract: We report a case of primary small-cell carcinoma of the ureter associated with adult polycystic kidney disease. A 72-year-old white man with history of adult polycystic kidney disease was first seen with gross hematuria. Cystoscopy revealed bloody efflux from the fight ureteral orifice. Computed tomography (CT) revealed a mass in the fight distal ureter. A right nephro-ureterectomy showed multicystic changes. The distal ureter contained a mass showing morphologic features and immunohistochemical staining pattern consistent with small-cell carcinoma, intermediate cell type. Interphase cytogenetics studies using fluorescence in situ hybridization (FISH) showed abnormal chromosomal numbers for a number of chromosomes, including an interesting finding of nulliploidy of chromosome 3. Aneuploid populations of tumor cells and a high S-phase fraction also were detected by flow cytometry. The significance of these abnormalities of this rare tumor, with regard to their association to the tumor's biologic behavior and their role in tumorigenesis, is discussed.
Keywords: immunohistochemistry; human tissue; aged; case report; flow cytometry; computer assisted tomography; hematuria; nephrectomy; fluorescence in situ hybridization; cystoscopy; ureter; ureter carcinoma; aneuploidy; small cell carcinoma; chromosome 3; kidney polycystic disease; interphase; small-cell carcinoma; chromosome number; human; male; priority journal; article; adult polycystic kidney disease; case report fish
Journal Title: Applied Immunohistochemistry & Molecular Morphology
Volume: 7
Issue: 2
ISSN: 1541-2016
Publisher: Lippincott Williams & Wilkins  
Date Published: 1999-01-01
Start Page: 164
End Page: 168
Language: English
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032837635&partnerID=40&md5=4e1d4286863f82f112eaca270f113f5f
Notes: Article -- Export Date: 16 August 2016 -- Source: Scopus