Six-year follow-up of patients with microinvasive, T1a, and T1b breast carcinoma Journal Article
| Authors: | Mann, G. B.; Rush Port, E.; Rizza, C.; Tan, L. K.; Borgen, P. I.; Van Zee, K. J. |
| Article Title: | Six-year follow-up of patients with microinvasive, T1a, and T1b breast carcinoma |
| Abstract: | Background: Management of patients with breast cancers ≤ 1 cm remains controversial. Reports of infrequent nodal metastases in tumors ≤5 mm has led to suggestions that axillary dissection should be selective, and that tumor characteristics should guide adjuvant therapy. Methods: A retrospective review of 290 patients with breast cancer 1 cm in size or smaller from 1989 to 1991 was done. Distant disease-free survival (DDFS) was the primary outcome measure. Results: There were 95 T1a (≤5 mm) and 196 T1b (6-10 mm) cancers. Nodal metastases were found in 8 T1a and 26 T1b tumors. Larger size, poorer differentiation, and lymphovascular invasion (LVI) were associated with more nodal metastases, but none of these trends reached statistical significance. The 6-year DDFS was 93 % for node-negative and 87% for node- positive patients (P = .02). Overall, breast cancers with poorer differentiation and LVI trended toward a poorer outcome. For patients with node-negative tumors, LVI was associated with a poorer outcome (P = .03). The size of the primary tumor was not predictive of outcome. There were no nodal metastases or recurrences in the 18 patients with microinvasive breast cancer. Conclusions: Lymph node status is the major determinant of outcome in breast cancers 1 cm in size or smaller. Accurate axillary assessment remains crucial in management of small breast cancer. |
| Keywords: | adult; treatment outcome; aged; aged, 80 and over; disease-free survival; middle aged; survival analysis; retrospective studies; major clinical study; cancer radiotherapy; radiotherapy, adjuvant; recurrent cancer; follow up; follow-up studies; lymph node metastasis; lymph nodes; lymphatic metastasis; lymph node excision; lymphadenectomy; mastectomy; tumor volume; tumor differentiation; pathology; breast neoplasms; retrospective study; breast carcinoma; neoplasm invasiveness; axilla; axillary dissection; sentinel node biopsy; early breast cancer; regional metastases; humans; human; female; article; axillary lymph node metastases; microinvasive breast cancer; minimal breast cancer; prognosis disease-free survival |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 6 |
| Issue: | 6 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 1999-09-01 |
| Start Page: | 591 |
| End Page: | 598 |
| Language: | English |
| DOI: | 10.1007/s10434-999-0591-5 |
| PUBMED: | 10493629 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
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