Prioritization schema for immunotherapy clinical trials in glioblastoma Journal Article


Authors: Hodges, T. R.; Ferguson, S. D.; Caruso, H. G.; Kohanbash, G.; Zhou, S. H.; Cloughesy, T. F.; Berger, M. S.; Poste, G. H.; Khasraw, M.; Ba, S. J.; Jiang, T.; Mikkelson, T.; Yung, W. K. A.; de Groot, J. F.; Fine, H.; Cantley, L. C.; Mellinghoff, I. K.; Mitchell, D. A.; Okada, H.; Heimberger, A. B.
Article Title: Prioritization schema for immunotherapy clinical trials in glioblastoma
Abstract: Background: Emerging immunotherapeutic strategies for the treatment of glioblastoma (GBM) such as dendritic cell (DC) vaccines, heat shock proteins, peptide vaccines, and adoptive T-cell therapeutics, to name a few, have transitioned from the bench to clinical trials. With upcoming strategies and developing therapeutics, it is challenging to critically evaluate the practical, clinical potential of individual approaches and to advise patients on the most promising clinical trials. Methods: The authors propose a system to prioritize such therapies in an organized and data-driven fashion. This schema is based on four categories of factors: antigenic target robustness, immune-activation and -effector responses, preclinical vetting, and early evidence of clinical response. Each of these categories is subdivided to focus on the most salient elements for developing a successful immunotherapeutic approach for GBM, and a numerical score is generated. Results: The Score Card reveals therapeutics that have the most robust data to support their use, provides a reference prioritization score, and can be applied in a reiterative fashion with emerging data. Conclusions: The authors hope that this schema will give physicians an evidence-based and rational framework to make the best referral decisions to better guide and serve this patient population.
Keywords: clinical trial; immunotherapy; glioblastoma; chimeric antigen receptor; stem-cells; tumor-infiltrating lymphocytes; regulatory t-cells; growth-factor receptor; phase-iii trial; herpes-simplex-virus; high-grade glioma; newly-diagnosed; recurrent malignant glioma; prioritization; cancer; score card
Journal Title: OncoImmunology
Volume: 5
Issue: 6
ISSN: 2162-4011
Publisher: Landes Bioscience  
Date Published: 2016-01-01
Language: English
ACCESSION: WOS:000379162700007
DOI: 10.1080/2162402x.2016.1145332
PROVIDER: wos
PMCID: PMC4938323
PUBMED: 27471611
Notes: Review -- e1145332 -- Source: Wos
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