Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: Evidence from the Ovarian Cancer Association Consortium Journal Article


Authors: Cannioto, R. A.; LaMonte, M. J.; Kelemen, L. E.; Risch, H. A.; Eng, K. H.; Minlikeeva, A. N.; Hong, C. C.; Szender, J. B.; Sucheston-Campbell, L.; Joseph, J. M.; Berchuck, A.; Chang-Claude, J.; Cramer, D. W.; DeFazio, A.; on behalf of The Australian Ovarian Cancer Study Group; Diergaarde, B.; Dörk, T.; Doherty, J. A.; Edwards, R. P.; Fridley, B. L.; Friel, G.; Goode, E. L.; Goodman, M. T.; Hillemanns, P.; Hogdall, E.; Hosono, S.; Kelley, J. L.; Kjaer, S. K.; Klapdor, R.; Matsuo, K.; Odunsi, K.; Nagle, C. M.; Olsen, C. M.; Paddock, L. E.; Pearce, C. L.; Pike, M. C.; Rossing, M. A.; Schmalfeldt, B.; Segal, B. H.; Szamreta, E. A.; Thompson, P. J.; Tseng, C. C.; Vierkant, R.; Schildkraut, J. M.; Wentzensen, N.; Wicklund, K. G.; Winham, S. J.; Wu, A. H.; Modugno, F.; Ness, R. B.; Jensen, A.; Webb, P. M.; Terry, K.; Bandera, E. V.; Moysich, K. B.
Article Title: Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: Evidence from the Ovarian Cancer Association Consortium
Abstract: Background: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality. Methods: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years. Results: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR = 1.34, 95% CI: 1.18-1.52) and without (HR = 1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively. Conclusion: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.
Keywords: survival; risk; epithelial ovarian cancer; prognostic-factors; cohort; polymorphisms; hormone-therapy; inactivity; recreational physical activity; mortality risk
Journal Title: British Journal of Cancer
Volume: 115
Issue: 1
ISSN: 0007-0920
Publisher: Nature Publishing Group  
Date Published: 2016-06-28
Start Page: 95
End Page: 101
Language: English
ACCESSION: WOS:000378880400015
DOI: 10.1038/bjc.2016.153
PROVIDER: wos
PMCID: PMC4931371
PUBMED: 27299959
Notes: Article -- Source: Wos
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  1. Malcolm Pike
    190 Pike