Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages Journal Article

   


Authors: Emile, J. F.; Abla, O.; Fraitag, S.; Horne, A.; Haroche, J.; Donadieu, J.; Requena-Caballero, L.; Jordan, M. B.; Abdel-Wahab, O.; Allen, C. E.; Charlotte, F.; Diamond, E. L.; Egeler, R. M.; Fischer, A.; Herrera, J. G.; Henter, J. I.; Janku, F.; Merad, M.; Picarsic, J.; Rodriguez-Galindo, C.; Rollins, B. J.; Tazi, A.; Vassallo, R.; Weiss, L. M.; for the Histiocyte Society
Article Title: Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages
Abstract: The histiocytoses are rare disorders characterized by the accumulation of macrophage, dendritic cell, or monocyte-derived cells in various tissues and organs of children and adults. More than 100 different subtypes have been described, with a wide range of clinical manifestations, presentations, and histologies. Since the first classification in 1987, a number of new findings regarding the cellular origins, molecular pathology, and clinical features of histiocytic disorders have been identified. We propose herein a revision of the classification of histiocytoses based on histology, phenotype, molecular alterations, and clinical and imaging characteristics. This revised classification system consists of 5 groups of diseases: (1) Langerhans-related, (2) cutaneous and mucocutaneous, and (3) malignanthistiocytoses as well as (4) Rosai-Dorfman disease and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. Herein, we provide guidelines and recommendations for diagnoses of these disorders.
Keywords: mutation; disease; central-nervous-system; braf(v600e); of-the-literature; hemophagocytic lymphohistiocytosis; sinus histiocytosis; massive lymphadenopathy; erdheim-chester-disease; igg4-related; rosai-dorfman-disease; activation syndrome
Journal Title: Blood
Volume: 127
Issue: 22
ISSN: 0006-4971
Publisher: American Society of Hematology  
Date Published: 2016-06-02
Start Page: 2672
End Page: 2681
Language: English
ACCESSION: WOS:000378335400009
DOI: 10.1182/blood-2016-01-690636
PROVIDER: wos
PUBMED: 26966089
PMCID: PMC5161007
Notes: Review -- Source: Wos
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MSK Authors
  1. Omar Ibrahim Abdel-Wahab
    575 Abdel-Wahab
  2. Eli Louis Diamond
    204 Diamond
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