Outcomes of chemotherapies and HER2 directed therapies in advanced HER2-mutant lung cancers Journal Article
| Authors: | Eng, J.; Hsu, M.; Chaft, J. E.; Kris, M. G.; Arcila, M. E.; Li, B. T. |
| Article Title: | Outcomes of chemotherapies and HER2 directed therapies in advanced HER2-mutant lung cancers |
| Abstract: | Human epidermal growth factor receptor 2 (HER2, ERBB2) mutations occur in 3% of lung adenocarcinomas. While case reports and series have shown activity of HER2 targeted agents in these patients, little is known about outcomes of chemotherapies. Patients with stage IV HER2-mutant lung cancers at Memorial Sloan Kettering were reviewed. Patient demographics, types of HER2 mutations, duration of systemic treatments and survival were analyzed. We identified 38 patients with HER2-mutant lung cancers: median age 62; majority were women (n = 24), never smokers (n = 22), and all had adenocarcinomas. A 12 base pair in-frame insertion YVMA in exon 20 (p.A775_G776insYVMA) was present in 24 (63%, 95% CI 46–78%) patients. In addition, there were four 9 base pair insertions, one 6 base pair insertion, and five 3 base pair insertions in exon 20, and four single bp substitutions (exon 20 L755F, V777L, D769H, exon 8 S310F). The median overall survival from date of diagnosis of stage IV disease was 2.3 years (95% CI 1.2-2.6). The median duration of chemotherapy was 4.3 months (68 treatments, range 0–21 months): 6.2 months for pemetrexed ±platinum/bevacizumab, 4 months for taxane ±platinum/bevacizumab, 2.6 months for gemcitabine, 3.5 months for vinorelbine. The median duration of HER2 tyrosine kinase inhibitors was 2.2 months (28 treatments, range 0.3-16.3 months). As we search for better targeted therapies for patients with HER2-mutant lung cancers, chemotherapy remains an important component of care. © 2016 Elsevier Ireland Ltd |
| Keywords: | mutation; chemotherapy; lung cancer; targeted therapy; human epidermal growth factor receptor 2 (her2) |
| Journal Title: | Lung Cancer |
| Volume: | 99 |
| ISSN: | 0169-5002 |
| Publisher: | Elsevier Ireland Ltd. |
| Date Published: | 2016-09-01 |
| Start Page: | 53 |
| End Page: | 56 |
| Language: | English |
| DOI: | 10.1016/j.lungcan.2016.05.030 |
| PROVIDER: | scopus |
| PMCID: | PMC5305295 |
| PUBMED: | 27565914 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 August 2016 -- Source: Scopus |
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