Chromophobe renal cell carcinoma: A clinicopathologic study of 203 tumors in 200 patients with primary resection at a single institution Journal Article

  


Authors: Przybycin, C. G.; Cronin, A. M.; Darvishian, F.; Gopalan, A.; Al-Ahmadie, H. A.; Fine, S. W.; Chen, Y. B.; Bernstein, M.; Russo, P.; Reuter, V. E.; Tickoo, S. K.
Article Title: Chromophobe renal cell carcinoma: A clinicopathologic study of 203 tumors in 200 patients with primary resection at a single institution
Abstract: Despite multiple studies, many clinicopathologic issues about chromophobe renal cell carcinoma (RCC) remain contentious; for example, its biological behavior-whether better or similar to papillary RCC, the incidence of sarcomatoid features, and whether pathologic features such as necrosis, nuclear grade, and tumor stage predict worse outcome. We studied 203 consecutive primary chromophobe RCCs resected at our institution in an attempt to answer these and other questions. The tumors showed significant progressive decrease in size and stage (P=0.047 and 0.001) from 1980 to 2000. Five patients had metastasis at presentation, and further disease-specific events (recurrence/metastasis/death due to disease) occurred in 8 more. Only 4 of 203 tumors had sarcomatoid features. Over median follow-up of 6.1 years (range, 0.1 to 18 y), 5-year and 10-year disease-specific events occurred in 3.7% (95% CI, 1.5%, 7.4%) and 6.4% (95% CI, 2.7%, 12.2%) patients. Outcomes showed significant association with tumor size, small-vessel invasion, sarcomatoid features, and microscopic necrosis (P≤0.05 each). pT stage or nodal metastasis tended to show some association, without reaching statistical significance (P=0.05 and 0.06, respectively). A modified tumor grading scheme, somewhat similar to that proposed recently, mitotic index, cytologic eosinophilia, and architecture, were not significantly associated with outcome. In conclusion, sarcomatoid differentiation is quite uncommon in chromophobe RCC. Tumor size, small-vessel invasion, sarcomatoid differentiation, and microscopic necrosis are the only features that are significantly associated with adverse outcome. On the basis of this long follow-up on a large number of cases, chromophobes seem to have better clinical outcomes than those reported for clear cell and papillary RCCs. © 2011 Lippincott Williams & Wilkins.
Keywords: chromophobe; renal cell carcinoma; grading; clinicopathologic
Journal Title: American Journal of Surgical Pathology
Volume: 35
Issue: 7
ISSN: 0147-5185
Publisher: Lippincott Williams & Wilkins  
Date Published: 2011-07-01
Start Page: 962
End Page: 970
Language: English
DOI: 10.1097/PAS.0b013e31821a455d
PROVIDER: scopus
PUBMED: 21602658
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-79959648026&partnerID=40&md5=5206d66f8b06d482b126e08d80d0fe1d
Notes: --- - "Export Date: 17 August 2011" - "CODEN: AJSPD" - "Source: Scopus"
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MSK Authors
  1. Farbod Darvishian
    10 Darvishian
  2. Paul Russo
    581 Russo
  3. Satish K Tickoo
    478 Tickoo
  4. Christopher Gregory Przybycin
    4 Przybycin
  5. Anuradha Gopalan
    411 Gopalan
  6. Yingbei Chen
    393 Chen
  7. Angel M Cronin
    145 Cronin
  8. Samson W Fine
    457 Fine
  9. Hikmat Al-Ahmadie
    655 Al-Ahmadie
  10. Victor Reuter
    1223 Reuter
  11. Melanie Bernstein
    62 Bernstein
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