Synchronous epithelial and neuroendocrine cancers of the pancreas: Case series of a rare occurrence Journal Article


Authors: Power, D. G.; Shia, J.; Allen, P. J.; Jarnagin, W. R.; O'Reilly, E. M.
Article Title: Synchronous epithelial and neuroendocrine cancers of the pancreas: Case series of a rare occurrence
Abstract: The presence of neuroendocrine cells in adenocarcinomas is not an unusual finding and is well described in gastrointestinal tract cancers, eg, colorectal cancer and gastric cancer. Genetic analysis of such tumors has suggested a common multipotent progenitor stem cell origin. The prognostic significance of neuroendocrine cells in adenocarcinoma cells is unclear. There is a scant literature on synchronous pancreas ductal adenocarcinoma and pancreas neuroendocrine tumors. We report 2 cases with a purpose of discussing management strategies, prognosis, and potential etiologies of this rare presentation. © 2011 Published by Elsevier Inc.
Keywords: immunohistochemistry; adult; cancer chemotherapy; human tissue; middle aged; surgical technique; fatigue; histopathology; splenectomy; case report; cisplatin; sunitinib; artificial embolism; capecitabine; gemcitabine; pancreas resection; pancreatic neoplasms; temozolomide; lymph node dissection; adenocarcinoma; computer assisted tomography; etoposide; vomiting; ca 19-9 antigen; carcinoma, pancreatic ductal; weight reduction; tumor marker; irinotecan; neuroendocrine tumor; pruritus; bilirubin; liver metastasis; pancreas tumor; pancreas adenocarcinoma; jaundice; liver resection; stent; octreotide; aspiration biopsy; gastroesophageal reflux; cholecystectomy; liver biopsy; gallstone; neoplasms, multiple primary; hepatic artery; endoscopic echography; neuroendocrine tumors; chromogranin a; neurosecretory cell; hepatic artery ligation; wedge resection; collision tumors; mixed acinar-endocrine; pancreas neuroendocrine tumors; progenitor stem cell; bile duct stent; blood chemistry; common bile duct; magnetic resonance cholangiopancreatography; pancreas neuroendocrine tumor; whipple surgery
Journal Title: Clinical Colorectal Cancer
Volume: 10
Issue: 2
ISSN: 1533-0028
Publisher: Elsevier Inc.  
Date Published: 2011-06-01
Start Page: 146
End Page: 150
Language: English
DOI: 10.1016/j.clcc.2011.03.013
PROVIDER: scopus
PUBMED: 21859569
DOI/URL:
Notes: --- - "Export Date: 17 August 2011" - "CODEN: CCCLC" - "Source: Scopus"
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MSK Authors
  1. Jinru Shia
    503 Shia
  2. Peter Allen
    467 Allen
  3. William R Jarnagin
    623 Jarnagin
  4. Derek Gerard Power
    37 Power
  5. Eileen O'Reilly
    403 O'Reilly
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