Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland Journal Article


Authors: Baker, L.; BeGora, M.; Yeung, F. A.; Feigin, M. E.; Rosenberg, A. Z.; Lowe, S. W.; Kislinger, T.; Muthuswamy, S. K.
Article Title: Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland
Abstract: The cell polarity protein scribble (SCRIB) is a crucial regulator of polarization, cell migration and tumorigenesis. Whereas SCRIB is known to regulate early stages of mouse mammary gland development, its function in the adult gland is not known. Using an inducible RNA interference (RNAi) mouse model for downregulating SCRIB expression, we report an unexpected role for SCRIB as a positive regulator of cell proliferation during pregnancy-associated mammary alveologenesis. SCRIB was required in the epithelial cell compartment of the mammary gland. Lack of SCRIB attenuated prolactin-induced activation of the JAK2-STAT5 signaling pathway. In addition, loss of SCRIB resulted in the downregulation of prolactin receptor (PRLR) at cell surface and its accumulation in intracellular structures that express markers of the Golgi complex and the recycling endosome. Unlike its role in virgin gland as a negative regulator cell proliferation, SCRIB is a positive regulator of mammary epithelial cell proliferation during pregnancy. © 2016.
Keywords: proliferation; scribble; mammary alveologenesis
Journal Title: Journal of Cell Science
Volume: 129
Issue: 12
ISSN: 0021-9533
Publisher: Company of Biologists  
Date Published: 2016-06-15
Start Page: 2307
End Page: 2315
Language: English
DOI: 10.1242/jcs.185413
PROVIDER: scopus
PMCID: PMC4920253
PUBMED: 27179074
DOI/URL:
Notes: Article -- Export Date: 2 August 2016 -- Source: Scopus
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  1. Scott W Lowe
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