Biologically distinct subsets of nevi Journal Article
| Authors: | Rogers, T.; Marino, M. L.; Raciti, P.; Jain, M.; Busam, K. J.; Marchetti, M. A.; Marghoob, A. A. |
| Article Title: | Biologically distinct subsets of nevi |
| Abstract: | Melanocytic nevi (MN) encompass a range of benign tumors with varying microscopic and macroscopic features. Their development is a multifactorial process under genetic and environmental inluences. The clinical importance of MN lies in distinguishing them from melanoma and in recognizing their associations with melanoma risk and cancer syndromes. Historically, the distinction between the different types of MN, as well as between MN and melanoma, was based on clinical history, gross morphology, and histopathological features. While histopathology with clinical correlation remains the gold standard for differentiating and diagnosing melanocytic lesions, in some cases, this may not be possible. The use of dermoscopy has allowed for the assessment of subsurface skin structures and has contributed to the clinical evaluation and classiication of MN. Genetic proiling, while still in its early stages, has the greatest potential to reine the classiication of MN by clarifying their developmental processes, biological behaviors, and relationships to melanoma. Here we review the most salient clinical, dermoscopic, histopathological, and genetic features of different MN subgroups. © 2015 Edizioni Minerva Medica. |
| Keywords: | genetics; dermoscopy; nevus; dysplastic nevus syndrome; pigmented; blue; epithelioid and spindle cell |
| Journal Title: | Giornale Italiano di Dermatologia e Venereologia |
| Volume: | 151 |
| Issue: | 4 |
| ISSN: | 0392-0488 |
| Publisher: | Edizioni Minerva Medica |
| Date Published: | 2016-08-01 |
| Start Page: | 365 |
| End Page: | 384 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 27119653 |
| PMCID: | PMC5445663 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 August 2016 -- Source: Scopus |
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