Advances in the management of anal cancer Journal Article
| Authors: | Julie, D. R.; Goodman, K. A. |
| Article Title: | Advances in the management of anal cancer |
| Abstract: | Although anal squamous cell carcinoma (ASCC) is an uncommon malignancy, its incidence has been increasing markedly in recent decades due to its association with human papilloma virus (HPV) infection. The well-established standard of care for localized ASCC consists of the combination of 5-fluorouracil (5FU) and mitomycin (MMC) chemotherapy, concurrent with external beam radiation therapy (EBRT). However, newer techniques are being actively pursued, including the use of newer radiation therapy (RT) technologies, such as intensity-modulated radiation therapy (IMRT). The areas of debate and development include the dosing and timing of MMC delivery, the role of cisplatin chemotherapy as an alternative to MMC, the replacement of the standard 96-h infusion of 5FU with oral capecitabine, the use of targeted chemotherapy agents, and the duration and dose of RT. © 2016, Springer Science+Business Media New York. |
| Keywords: | cancer survival; review; cancer localization; cancer recurrence; intensity modulated radiation therapy; squamous cell carcinoma; cisplatin; treatment duration; capecitabine; cancer radiotherapy; disease association; prevalence; cancer screening; cetuximab; minimal residual disease; intensity-modulated radiotherapy; vaccination; cancer epidemiology; mitomycin; anus cancer; induction chemotherapy; rectum abdominoperineal resection; randomized controlled trial (topic); phase 3 clinical trial (topic); papillomavirus infection; anal cancer; human papilloma virus; cancer prognosis; radiation dose escalation; definitive chemoradiation; human; anal squamous cell carcinoma |
| Journal Title: | Current Oncology Reports |
| Volume: | 18 |
| Issue: | 3 |
| ISSN: | 1523-3790 |
| Publisher: | Springer |
| Date Published: | 2016-03-01 |
| Start Page: | 20 |
| Language: | English |
| DOI: | 10.1007/s11912-016-0503-3 |
| PROVIDER: | scopus |
| PUBMED: | 26905274 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 August 2016 -- Source: Scopus |
