Sorafenib-associated multivessel coronary artery vasospasm Journal Article
| Authors: | Naib, T.; Steingart, R. M.; Chen, C. |
| Article Title: | Sorafenib-associated multivessel coronary artery vasospasm |
| Abstract: | Cardiotoxicity associated with cancer treatment is an important field of interest especially as the new class of VEGF signaling pathway inhibitors (VSP) continues to grow. Small molecule tyrosine kinase inhibitors such as sorafenib, sunitinib, and pazopanib inhibit the downstream pathways of all three of the vascular endothelial growth factor receptors (VEGFR 1, 2, and 3). Other targets of these agents include kinases involved in vascular and myocardial homoeostasis. These agents are all known to frequently cause hypertension, their most common side-effect. Myocardial ischemia has also been reported, but the frequency and etiology of VSP-related ischemia is poorly characterized. This manuscript describes the first reported case of sorafenib-associated multivessel coronary vasospasm in a 57-year-old patient with hepatocellular carcinoma. He underwent sorafenib treatment, a tyrosinase inhibitor, 400 mg twice a day. The vasospasm was reversible under nitroglycerin. Possible mechanisms are also discussed. © 2011 Urban & Vogel. |
| Keywords: | adult; treatment outcome; middle aged; clinical feature; disease course; case report; sorafenib; drug dose reduction; drug withdrawal; hypertension; liver cell carcinoma; antineoplastic agents; benzenesulfonates; pyridines; bone metastasis; gemcitabine; protein blood level; kidney failure; backache; chill; dizziness; dyspnea; cause of death; hypotension; thorax pain; acetylsalicylic acid; thrombosis; diabetes mellitus; heparin; recurrent disease; oral antidiabetic agent; physical examination; oxaliplatin; electrocardiography; dipeptidyl carboxypeptidase inhibitor; dopamine; drug induced disease; multiple organ failure; abdominal discomfort; angiopoietin; angiocardiography; indigestion; troponin; coronary spasm; glyceryl trinitrate; artery lesion; coronary artery spasm; coronary vasospasm |
| Journal Title: | Herz |
| Volume: | 36 |
| Issue: | 4 |
| ISSN: | 0340-9937 |
| Publisher: | Urban & Vogel |
| Date Published: | 2011-06-01 |
| Start Page: | 348 |
| End Page: | 351 |
| Language: | English |
| DOI: | 10.1007/s00059-011-3444-5 |
| PROVIDER: | scopus |
| PUBMED: | 21584715 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 17 August 2011" - "CODEN: HERZD" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work