A role for PML in innate immunity Journal Article

   


Authors: Lunardi, A.; Gaboli, M.; Giorgio, M.; Rivi, R.; Bygrave, A.; Antoniou, M.; Drabek, D.; Dzierzak, E.; Fagioli, M.; Salmena, L.; Botto, M.; Cordon-Cardo, C.; Luzzatto, L.; Pelicci, P. G.; Grosveld, F.; Pandolfi, P. P.
Article Title: A role for PML in innate immunity
Abstract: The promyelocytic leukemia gene (PML) of acute promyelocytic leukemia is an established tumor suppressor gene with critical functions in growth suppression, induction of apoptosis, and cellular senescence. Interestingly, although less studied, PML seems to play a key role also in immune response to viral infection. Herein, we report that Pml-/- mice spontaneously develop an atypical invasive and lethal granulomatous lesion known as botryomycosis (BTM). In Pml-/- mice, BTM is the result of impaired function of macrophages, whereby they fail to become activated and are thus unable to clear pathogenic microorganisms. Accordingly, Pml-/- mice are resistant to lipopolysaccharide (LPS)-induced septic shock as a result of an ineffective production of cytokines and chemokines, suggesting a role for PML in the innate immune Toll-like receptor (TLR)/NF-κB prosurvival pathway. These results not only shed light on a new fundamental function of PML in innate immunity, but they also point to a proto-oncogenic role for PML in certain cellular and pathological contexts. © The Author(s) 2011.
Keywords: controlled study; hepatitis; nonhuman; cell proliferation; mouse; animal tissue; mus; cell infiltration; animal experiment; animal model; tumor suppressor gene; plasma cell; splenomegaly; escherichia coli; interleukin 6; lipopolysaccharide; cytokine production; innate immunity; atelectasis; salivary gland; immunoglobulin g1; enterococcus; staphylococcus aureus; phagocytosis; immunoglobulin blood level; antibiotic sensitivity; leukocytosis; listeria monocytogenes; lethality; lysosome; immunoglobulin e; abscess; experimental infection; septic shock; extramedullary hematopoiesis; ampicillin; macrophage activation; pml; lung emphysema; klebsiella pneumoniae; botryomycosis; lung alveolus wall; macrophage function; lymph node hyperplasia; promyelocytic leukemia gene; proteus mirabilis
Journal Title: Genes and Cancer
Volume: 2
Issue: 1
ISSN: 1947-6019
Publisher: Sage Publications  
Date Published: 2011-01-01
Start Page: 10
End Page: 19
Language: English
DOI: 10.1177/1947601911402682
PROVIDER: scopus
PMCID: PMC3111006
PUBMED: 21779477
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-79960061702&partnerID=40&md5=6417b7f1f4bb85826e51d067c7d69cee
Notes: --- - "Export Date: 17 August 2011" - "Source: Scopus"
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MSK Authors
  1. Mirella P Gaboli
    19 Gaboli
  2. Pier Paolo Pandolfi Derinaldis
    353 Pandolfi Derinaldis
  3. Carlos Cordon-Cardo
    612 Cordon-Cardo
  4. Roberta Rivi
    25 Rivi
  5. Lucio Luzzatto
    105 Luzzatto
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