Combinatorial cancer immunotherapies Journal Article
| Authors: | Hellmann, M. D.; Friedman, C. F.; Wolchok, J. D. |
| Article Title: | Combinatorial cancer immunotherapies |
| Title Series: | Advances in Immunology |
| Abstract: | T cell checkpoint blockade therapies are revolutionizing the treatment of patients with cancer. Highlighted by the recent success of PD-1 plus CTLA-4 blockade in patients with melanomas, synergistic immunotherapy combinations of modalities represent an important opportunity to improve responses and outcomes for patients. We review the rationale and experience with T cell checkpoint blockade in combination with targeting of other coinhibitory or costimulatory checkpoints, immunomodulatory molecules in the tumor microenvironment, and other anticancer modalities such as vaccines, chemotherapy, and radiation. |
| Keywords: | metastatic melanoma; tumor-infiltrating lymphocytes; cell lung-cancer; regulatory t-cells; growth-factor receptor; antitumor immunity; chronic viral-infection; recombinant interleukin-2 therapy; tryptophan catabolism; b16 melanoma tumors |
| Journal Title: | Advances in Immunology |
| Volume: | 130 |
| ISSN: | 0065-2776 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2016-01-01 |
| Start Page: | 251 |
| End Page: | 277 |
| Language: | English |
| ACCESSION: | WOS:000375653100007 |
| PROVIDER: | wos |
| PUBMED: | 26923003 |
| DOI: | 10.1016/bs.ai.2015.12.005 |
| Notes: | Chapter 6 in "Tumor Immunology" (ISBN: 9780128047996) -- Source: Wos |
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