Quality of life among patients after bilateral prophylactic mastectomy: A systematic review of patient-reported outcomes Journal Article
| Authors: | Razdan, S. N.; Patel, V.; Jewell, S.; McCarthy, C. M. |
| Article Title: | Quality of life among patients after bilateral prophylactic mastectomy: A systematic review of patient-reported outcomes |
| Abstract: | Bilateral prophylactic mastectomy (BPM) is effective in reducing the risk of breast cancer in women with a well-defined family history of breast cancer or in women with BRCA 1 or 2 mutations. Evaluating patient-reported outcomes following BPM are thus essential for evaluating success of BPM from patient's perspective. Our systematic review aimed to: (1) identify studies describing health-related quality of life (HRQOL) in patients following BPM with or without reconstruction; (2) assess the effect of BPM with or without reconstruction on HRQOL; and (3) identify predictors of HRQOL post-BPM. We performed a systematic review of literature using the PRISMA guidelines. PubMed, Embase, PsycINFO, Web of Science, Scopus and Cochrane databases were searched. The initial search resulted in 1082 studies; 22 of these studies fulfilled our inclusion criteria. Post-BPM, patients are satisfied with the outcomes and report high psychosocial well-being and positive body image. Sexual well-being and somatosensory function are most negatively affected. Vulnerability, psychological distress and preoperative cancer distress are significant negative predictors of quality of life and body image post-BPM. There is a paucity of high-quality data on outcomes of different HRQOL domains post-BPM. Future studies should strive to use validated and breast-specific PRO instruments for measuring HRQOL. This will facilitate shared decision-making by enabling surgeons to provide evidence-based answers to women contemplating BPM. |
| Keywords: | systematic review; surgery; satisfaction; patient-reported outcomes; brca2; predictors; women; mutation carriers; life; bilateral prophylactic mastectomy; body-image; family-history; quality of; immediate breast reconstruction; cancer-risk; risk-reducing mastectomy; risk reducing mastectomy |
| Journal Title: | Quality of Life Research |
| Volume: | 25 |
| Issue: | 6 |
| ISSN: | 0962-9343 |
| Publisher: | Springer |
| Date Published: | 2016-06-01 |
| Start Page: | 1409 |
| End Page: | 1421 |
| Language: | English |
| ACCESSION: | WOS:000376652200008 |
| DOI: | 10.1007/s11136-015-1181-6 |
| PROVIDER: | wos |
| PMCID: | PMC4867133 |
| PUBMED: | 26577764 |
| Notes: | Review -- SI -- Source: Wos |
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