Consolidation with bortezomib and dexamethasone following risk-adapted melphalan and stem cell transplant in systemic AL amyloidosis Journal Article

  

Authors:	Landau, H.; Hassoun, H.; Bello, C.; Hoover, E.; Riedel, E. R.; Nimer, S. D.; Comenzo, R. L.
Article Title:	Consolidation with bortezomib and dexamethasone following risk-adapted melphalan and stem cell transplant in systemic AL amyloidosis
Abstract:	High-dose melphalan and autologous stem cell transplant (SCT) induce hematologic and clinical remissions in AL and results in prolonged survival. In a prior phase II study, we showed that post-SCT adjuvant thalidomide and dexamethasone improved hematologic responses in 42% of patients, resulting in a 39% strictly defined complete response (sCR) rate at 12 months post-SCT (Cohen et al., Br J Haematol 2007;139:224-233). With a median follow-up of 59 months, the overall survival of patients on that study is 69% (Comenzo, Blood 2009;114:3147-3157). We now report on a phase II trial in which we use bortezomib and dexamethasone (BD) following risk-adapted SCT in newly diagnosed patients with amyloidosis who had residual disease following SCT. We show that BD is welltolerated and effective for eradicating persistent clonal plasma cell disease. At 12 months post-SCT, consolidation with BD achieves high overall and unprecedented sCR rates with frequent organ improvement that continues to occur over time. © 2011 Informa UK, Ltd.
Keywords:	adult; clinical article; treatment response; overall survival; thalidomide; disease course; drug efficacy; treatment duration; adjuvant therapy; drug megadose; follow up; bortezomib; infection; multiple cycle treatment; thrombocytopenia; peripheral neuropathy; dexamethasone; melphalan; amyloidosis; autologous stem cell transplantation; risk assessment; gastrointestinal toxicity; remission; immunoglobulin light chain; light chain amyloidosis; brain natriuretic peptide; troponin i
Journal Title:	Amyloid
Volume:	18
Issue:	Suppl. 1
ISSN:	1350-6129
Publisher:	Taylor & Francis Group
Date Published:	2011-06-01
Start Page:	135
End Page:	136
Language:	English
DOI:	10.3109/13506129.2011.574354
PROVIDER:	scopus
PUBMED:	21838462
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-79959927379&partnerID=40&md5=8ca8958a94604e404f7ca7d4c56e858a
Notes:	--- - "Export Date: 17 August 2011" - "CODEN: AIJIE" - "Source: Scopus"

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