From cloning neural development genes to functional studies in mice, 30 years of advancements Journal Article
| Author: | Joyner, A. L. |
| Article Title: | From cloning neural development genes to functional studies in mice, 30 years of advancements |
| Title Series: | Current Topics in Developmental Biology |
| Abstract: | The invention of new mouse molecular genetics techniques, initiated in the 1980s, has repeatedly expanded our ability to tackle exciting developmental biology problems. The brain is the most complex organ, and as such the more sophisticated the molecular genetics technique, the more impact they have on uncovering new insights into how our brain functions. I provide a general time line for the introduction of new techniques over the past 30 years and give examples of new discoveries in the neural development field that emanated from them. I include a look to what the future holds and argue that we are at the dawn of a very exciting age for young scientists interested in studying how the nervous system is constructed and functions with such precision. |
| Keywords: | homologous recombination; transgenic mice; mouse embryos; embryonic stem-cells; prostate-cancer; hedgehog; mammary-gland; sonic; rhombic-lip; inhibitory interneurons; homeotic genes |
| Journal Title: | Current Topics in Developmental Biology |
| Volume: | 116 |
| ISSN: | 0070-2153 |
| Publisher: | Academic Press, Elsevier Inc |
| Date Published: | 2016-01-01 |
| Start Page: | 501 |
| End Page: | 515 |
| Language: | English |
| ACCESSION: | WOS:000376939100029 |
| PROVIDER: | wos |
| PUBMED: | 26970637 |
| DOI: | 10.1016/bs.ctdb.2015.11.035 |
| Notes: | Book Chapter 28 in "Essays on Developmental Biology, Pt A" (ISBN: 978-0-12-802956-5 ) -- Source: Wos |
