Background parenchymal enhancement at breast MR imaging and breast cancer risk Journal Article

Authors: King, V.; Brooks, J. D.; Bernstein, J. L.; Reiner, A. S.; Pike, M. C.; Morris, E. A.
Article Title: Background parenchymal enhancement at breast MR imaging and breast cancer risk
Abstract: Purpose: To examine the relationships between breast cancer and both amount of fibroglandular tissue (FGT) and level of background parenchymal enhancement (BPE) at magnetic resonance (MR) imaging. Materials and Methods: A waiver of authorization was granted by the institutional review board for this retrospective HIPAA-compliant study. Among 1275 women who underwent breast MR imaging screening between December 2002 and February 2008, 39 breast carcinoma cases were identified. Two comparisons were performed: In one comparison, two normal controls - those of the women with negative (benign) findings at breast MR imaging - were matched to each breast cancer case on the basis of age and date of MR imaging. In the second comparison, one false-positive control - that of a woman with suspicious but nonmalignant findings at MR imaging - was similarly matched to each breast cancer case. Two readers independently rated the level of MR imaging-depicted BPE and the amount of MR imaging-depicted FGT by using a categorical scale: BPE was categorized as minimal, mild, moderate, or marked, and FGT was categorized as fatty, scattered, heterogeneously dense, or dense. Results: Compared with the odds ratio (OR) for a normal control, the OR for breast cancer increased significantly with increasing BPE: The ORs for moderate or marked BPE versus minimal or mild BPE were 10.1 (95% confidence interval [CI]: 2.9, 35.3; P < .001) and 3.3 (95% CI: 1.3, 8.3; P = .006) for readers 1 and 2, respectively. Similar odds were seen when the false-positive controls were compared with the breast cancer cases: The ORs for moderate or marked BPE versus minimal or mild BPE were 5.1 (95% CI: 1.4, 19.1; P = .005) and 3.7 (95% CI: 1.2, 11.2; P = .013) for readers 1 and 2, respectively. The breast cancer odds also increased with increasing FGT, but the BPE findings remained significant after adjustment for FGT. Conclusion: Increased BPE is strongly predictive of breast cancer odds. © RSNA, 2011.
Keywords: adult; controlled study; aged; major clinical study; cancer risk; nuclear magnetic resonance imaging; image analysis; breast; retrospective study; risk assessment; correlation analysis; image enhancement; breast carcinoma; false positive result; predictive value; background parenchymal enhancement; breast fibroglandular tissue
Journal Title: Radiology
Volume: 260
Issue: 1
ISSN: 0033-8419
Publisher: Radiological Society of North America, Inc.  
Date Published: 2011-07-01
Start Page: 50
End Page: 60
Language: English
DOI: 10.1148/radiol.11102156
PROVIDER: scopus
PUBMED: 21493794
Notes: --- - "Export Date: 17 August 2011" - "CODEN: RADLA" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Anne S Reiner
    122 Reiner
  2. Malcolm Pike
    133 Pike
  3. Elizabeth A Morris
    247 Morris
  4. Valencia King
    7 King
  5. Jonine L Bernstein
    104 Bernstein
  6. Jennifer Brooks
    17 Brooks