MEK inhibitor treatment is effective in a patient with metastatic carcinoma of the ampulla of Vater with BRAF and NRAS mutations shown by next-generation sequencing Journal Article
| Authors: | Tahover, E.; Bar Shalom, R.; Bogot, N.; Kelsen, D.; Gabizon, A. |
| Article Title: | MEK inhibitor treatment is effective in a patient with metastatic carcinoma of the ampulla of Vater with BRAF and NRAS mutations shown by next-generation sequencing |
| Abstract: | Here, we present a case of an 84-year-old woman who developed obstructive jaundice and was diagnosed with nonoperable adenocarcinoma originating from the ampulla of Vater, a lethal disease with a median overall survival of less than a year. Her tumor was examined by next-generation sequencing, which showed BRAF and NRAS mutations. To target these mutations, a MEK inhibitor was chosen for treatment. The patient has been treated with a MEK inhibitor for the last 12 months since diagnosis, with clinical and laboratory improvement and manageable side effects. PET-computed tomography imaging has shown stable disease or improvement in the primary and metastatic lesions. This is the first case report of an ampulla of a Vater cancer patient with NRAS and BRAF mutations, identified in next-generation sequencing, and treated successfully with a MEK inhibitor. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved. |
| Keywords: | gene; melanoma; therapy; braf; targeted; sequencing; nras; b-raf; mek inhibitor; craf; biliary-tract cancer; next-generation; carcinoma of the ampulla of vater; intrahepatic cholangiocarcinomas |
| Journal Title: | Anti-Cancer Drugs |
| Volume: | 27 |
| Issue: | 6 |
| ISSN: | 0959-4973 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2016-07-01 |
| Start Page: | 569 |
| End Page: | 572 |
| Language: | English |
| ACCESSION: | WOS:000377127300010 |
| DOI: | 10.1097/cad.0000000000000355 |
| PROVIDER: | wos |
| PUBMED: | 27075779 |
| Notes: | Article -- Source: Wos |
