A pilot study evaluating serum MMP7 as a preoperative prognostic marker for pancreatic ductal adenocarcinoma patients Journal Article
| Authors: | Wang, S. C.; Parekh, J. R.; Porembka, M. R.; Nathan, H.; D’Angelica, M. I.; DeMatteo, R. P.; Fong, Y.; Kingham, T. P.; Jarnagin, W. R.; Allen, P. J. |
| Article Title: | A pilot study evaluating serum MMP7 as a preoperative prognostic marker for pancreatic ductal adenocarcinoma patients |
| Abstract: | Background: Current preoperative risk stratification modalities for pancreatic ductal adenocarcinoma (PDA) patients are inadequate. Elevated serum matrix metalloproteinase 7 (MMP7) is associated with metastatic PDA. We evaluated preoperative MMP7 level as a prognostic marker in patients with resectable PDA. Methods: From a prospectively maintained database, we identified PDA patients who underwent operation with curative intent from 2004 to 2008 and had serum collected preoperatively. MMP7 was measured by enzyme-linked immunosorbent assay. Patients were defined as having advanced disease if they were found to be unresectable at the time of operation or had nodal involvement on final pathology. Results: Preoperative serum samples were available for 134 patients. Using a cutoff of 13.5 ng/mL, MMP7 was highly predictive for advanced disease. For patients who underwent R0 resection, MMP7 > 13.5 ng/mL was strongly associated with N1 status, T3/T4 stage, moderate/poor differentiation, and perineural invasion. The median recurrence-free survival was 5.0 months in patients with MMP7 > 13.5 ng/mL versus 9.9 months for patients with lower values (P = 0.004). Conclusions: Very elevated serum MMP7 was highly predictive of unresectable disease and nodal involvement despite favorable preoperative cross-sectional imaging. MMP7 should be further evaluated as a biomarker to risk-stratify PDA patients prior to operation. © 2016 The Society for Surgery of the Alimentary Tract |
| Keywords: | pancreas cancer; biomarker; ca19-9; mmp7 |
| Journal Title: | Journal of Gastrointestinal Surgery |
| Volume: | 20 |
| Issue: | 5 |
| ISSN: | 1091-255X |
| Publisher: | Springer |
| Date Published: | 2016-05-01 |
| Start Page: | 899 |
| End Page: | 904 |
| Language: | English |
| DOI: | 10.1007/s11605-015-3057-z |
| PROVIDER: | scopus |
| PMCID: | PMC4851562 |
| PUBMED: | 26921028 |
| DOI/URL: | |
| Notes: | Presented as a poster at 67th Annual Cancer Symposium of the Society of Surgical Oncology (SSO) which took place March 12-15, 2014 in Phoenix, AZ-- Export Date: 1 July 2016 -- Article in Press -- Source: Scopus |
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501Allen -
908Jarnagin -
782D'Angelica -
618Kingham
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