Wilms tumor 1 mutations in the pathogenesis of acute myeloid leukemia Journal Article
| Authors: | Rampal, R.; Figueroa, M. E. |
| Article Title: | Wilms tumor 1 mutations in the pathogenesis of acute myeloid leukemia |
| Abstract: | Wilms tumor 1 (WT1) has long been implicated in acute myeloid leukemia. It has been described to be both overexpressedand mutated in different forms of acute myeloid leukemia, and overexpression has been reported to play a prognostic role in this disease. However, the precise mechanism through which WT1 may play a role in leukemogenesis has remained elusive. In recent years, new evidence has emerged that points towards a novel role of WT1 mutations in the deregulation of epigenetic programs in leukemic cells through its interaction with TET proteins. Herein we review the current status of the field and its therapeutic and prognostic implications in acute myeloid leukemia. © 2016 Ferrata Storti Foundation. |
| Keywords: | unclassified drug; gene mutation; gene sequence; human cell; overall survival; gene deletion; missense mutation; review; nonhuman; cell proliferation; phenotype; gene overexpression; stat3 protein; reverse transcription polymerase chain reaction; apoptosis; gene expression; embryonic stem cell; green fluorescent protein; gene function; chronic myeloid leukemia; protein p53; dna methylation; carcinogenesis; tumor suppressor gene; myelodysplastic syndrome; minimal residual disease; epigenetics; leukemia cell; leukemogenesis; gene repression; acute myeloblastic leukemia; alternative rna splicing; heat shock protein 90; hematopoiesis; bone marrow cell; wt1 protein; tumor growth; genetic predisposition; nonsense mutation; cd38 antigen; recurrence free survival; deregulation; polycomb repressive complex 2; cd34 antibody; human; prognostic assessment; denys drash syndrome; protein translocase; ten eleven translocation protein; wilms tumor 1 gene |
| Journal Title: | Haematologica |
| Volume: | 101 |
| Issue: | 6 |
| ISSN: | 0390-6078 |
| Publisher: | Ferrata Storti Foundation |
| Date Published: | 2016-05-31 |
| Start Page: | 672 |
| End Page: | 679 |
| Language: | English |
| DOI: | 10.3324/haematol.2015.141796 |
| PROVIDER: | scopus |
| PUBMED: | 27252512 |
| PMCID: | PMC5013955 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 July 2016 -- Source: Scopus |
