Therapeutic guide for mTOuRing through the braided kidney cancer genomic river Journal Article
| Authors: | Voss, M. H.; Hsieh, J. J. |
| Article Title: | Therapeutic guide for mTOuRing through the braided kidney cancer genomic river |
| Abstract: | mTORC1 inhibitors were first approved for the use in metastatic kidney cancer. However, observed treatment benefit was highly heterogeneous among patients. Through case-based cancer genomic sequencing of therapeutic outliers, we can begin to appreciate the convergent evolution of given cancer pathways/ phenotypes beyond genes in kidney cancer, like a braided river. © 2016 American Association for Cancer Research. |
| Keywords: | vasculotropin; somatic mutation; missense mutation; sunitinib; gene; progression free survival; gene frequency; kidney carcinoma; temsirolimus; cancer genetics; mammalian target of rapamycin; tuberin; pazopanib; pharmacogenetics; mutation rate; kidney cancer; vhl gene; axitinib; mammalian target of rapamycin inhibitor; loss of function mutation; kidney metastasis; everolimus; von hippel lindau protein; next generation sequencing; cancer prognosis; tsc2 gene; mtor gene; pbrm1 gene; human; priority journal; article; tsc1 gene |
| Journal Title: | Clinical Cancer Research |
| Volume: | 22 |
| Issue: | 10 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2016-05-15 |
| Start Page: | 2320 |
| End Page: | 2322 |
| Language: | English |
| DOI: | 10.1158/1078-0432.ccr-16-0035 |
| PROVIDER: | scopus |
| PUBMED: | 26920890 |
| PMCID: | PMC5431075 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 July 2016 -- Source: Scopus |
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