Molecular pathways: Isocitrate dehydrogenase mutations in cancer Journal Article


Authors: Clark, O.; Yen, K.; Mellinghoff, I. K.
Article Title: Molecular pathways: Isocitrate dehydrogenase mutations in cancer
Abstract: IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to α-ketoglutarate (α-KG) and concomitantly produce reduced NADPH from NADP. Mutations in the genes encoding IDH1 and IDH2 have recently been found in a variety of human cancers, most commonly glioma, acute myeloid leukemia (AML), chondrosarcoma, and intrahepatic cholangiocarcinoma. The mutant protein loses its normal enzymatic activity and gains a new ability to produce the "oncometabolite" R(-)-2- hydroxyglutarate (R-2-HG). R-2-HG competitively inhibits α-KG-dependent enzymes which play crucial roles in gene regulation and tissue homeostasis. Expression of mutant IDH impairs cellular differentiation in various cell lineages and promotes tumor development in cooperation with other cancer genes. First-generation inhibitors of mutant IDH have entered clinical trials, and have shown encouraging results in patients with IDH-mutant AML. This article summarizes recent progress in our understanding of the role of mutant IDH in tumorigenesis. © 2016 AACR.
Journal Title: Clinical Cancer Research
Volume: 22
Issue: 8
ISSN: 1078-0432
Publisher: American Association for Cancer Research  
Date Published: 2016-04-15
Start Page: 1837
End Page: 1842
Language: English
DOI: 10.1158/1078-0432.ccr-13-1333
PROVIDER: scopus
PMCID: PMC4834266
PUBMED: 26819452
DOI/URL:
Notes: Article -- Export Date: 1 July 2016 -- Source: Scopus
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  1. Owen Richard Clark
    4 Clark